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四甲基脲

四甲基脲用途

N,N,N',N'-四甲基脲的介电常数比较低,适于作碱催化的异构化、烷基化、氰化及其他缩合反应的溶剂。也用作乙炔和聚丙烯腈的溶剂。

本品是一种高效有机溶剂,它对于一般的有机化合物特别是芳香族化合物都能完全溶解,而且还是许多有机物合成反应的优良溶剂。

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四甲基脲名称

[ CAS 号 ]:
632-22-4

[ 中文名 ]:
1,1,3,3-四甲基脲

[ 英文名 ]:
Tetramethylurea

[中文别名 ]:

[英文别名 ]:

四甲基脲物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
175.2±0.0 °C at 760 mmHg

[ 熔点 ]:
−1 °C(lit.)

[ 分子式 ]:
C5H12N2O

[ 分子量 ]:
116.162

[ 闪点 ]:
53.9±11.1 °C

[ 精确质量 ]:
116.094963

[ PSA ]:
23.55000

[ LogP ]:
0.19

[ 外观性状 ]:
透明无色液体

[ 蒸汽压 ]:
1.2±0.3 mmHg at 25°C

[ 折射率 ]:
1.445

[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂分开存放

[ 水溶解性 ]:
miscible

四甲基脲MSDS

四甲基脲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU2625000
CHEMICAL NAME :
Urea, 1,1,3,3-tetramethyl-
CAS REGISTRY NUMBER :
632-22-4
BEILSTEIN REFERENCE NO. :
0773898
LAST UPDATED :
199710
DATA ITEMS CITED :
21
MOLECULAR FORMULA :
C5-H12-N2-O
MOLECULAR WEIGHT :
116.19
WISWESSER LINE NOTATION :
1N1&VN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
600 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1499 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
999 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
999 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
999 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
999 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
1800 mg/kg
SEX/DURATION :
female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982
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四甲基脲安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H360D

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
NA 1993 / PGIII

[ WGK德国 ]:
3

[ RTECS号 ]:
YU2625000

[ 海关编码 ]:
2924210090

四甲基脲合成路线

四甲基脲上下游产品

四甲基脲制备

目前,四甲基脲的主要制备方法有以下两种。
(1)二甲胺光气法 其反应式如下:
    上述反应中的热效应十分剧烈,因而在大量制备时较难控制,同时在分离操作上也存在一定困难。可以先将中间产物(1)分离出来,然后使其再与二甲胺发生作用。制备实例:取135g(1.17mol)40%二甲胺的水溶液加入装有搅拌器的四颈瓶中,瓶的外壁用冰盐混合物加以冷却;然后在搅拌下滴加107g中间产物(1),维持体系的液温在-10℃以下。滴加(1)的程序是:当加入(1)20ml后,就开始同时滴加40%液碱100ml,然后再加固碱60g。反应完毕,反应液形成两层,上层减压蒸馏后即得四甲基脲;
下层可用苯抽取,将抽取液去苯后分馏又可得四甲基脲,合计收率80%~85%。
(2)碳酸二苯酯氨解法
制备实例:向2140g(10mol)碳酸二苯酯中于冷却下通入二甲胺气流1150g(25mol)。然后在压力釜中加热到200℃(约2.0MPa)4h。冷却后,将反应物加入到71.5mol/L的氢氧化钠溶液中,搅拌均匀后,用乙醚抽提。分离出抽体液并进行减压分馏,收集60~66℃(1.73kPa)的馏分,共得四甲基脲850g(四甲基脲得常压沸点为74.5℃)。

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四甲基脲海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺(包括无环氨基甲酸酯)(包括其衍生物及盐). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

四甲基脲文献

Transformation of NIH3T3 mouse fibroblast cells by MUC16 mucin (CA125) is driven by its cytoplasmic tail.

Int. J. Oncol. 46(1) , 91-8, (2014)

MUC16 (CA125) is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer (EOC). Expression of MUC16 is not detectable in the epithelial surface of normal ovaries. MUC16 ...

Coordination chemistry study of hydrated and solvated lead(II) ions in solution and solid state.

Inorg. Chem. 50(3) , 1058-72, (2011)

The coordination chemistry of lead(II) in the oxygen donor solvents water, dimethylsulfoxide (dmso, Me(2)SO), N,N-dimethylformamide (dmf), N,N-dimethylacetamide (dma), N,N'-dimethylpropyleneurea (dmpu...

Solvent-induced lysozyme gels: rheology, fractal analysis, and sol-gel kinetics.

J. Colloid. Interface Sci. 289(2) , 394-401, (2005)

In this work, the gelation kinetics and fractal character of lysozyme gel matrices developed in tetramethylurea (TMU)-water media were investigated. Gelation times were determined from the temporal cr...


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相关化合物

【四甲基脲】化源网提供四甲基脲CAS号632-22-4,四甲基脲MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询四甲基脲上化源网,专业又轻松。>>电脑版:四甲基脲

标题:四甲基脲_MSDS_用途_密度_四甲基脲CAS号【632-22-4】_化源网 地址:https://m.chemsrc.com/mip/cas/632-22-4_509703.html