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苯扎氯铵

苯扎氯铵用途

苯扎氯铵(水中50%)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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苯扎氯铵名称

[ CAS 号 ]:
63449-41-2

[ 中文名 ]:
苯扎氯铵

[ 英文名 ]:
Benzalkonium chloride

[中文别名 ]:

[英文别名 ]:

N-Benzyl-N,N-dimethyl-1-decanaminium chloride
Benzyl-C8-18-alkyldimethylammonium chlorides
MFCD00145757
EINECS 264-151-6
N-benzyl-N,N-dimethyldecan-1-aminium chloride

苯扎氯铵生物活性

[ 描述 ]:

苯扎氯铵(水中50%)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

苯扎氯铵物理化学性质

[ 密度 ]:
0.989 g/cm3

[ 沸点 ]:
100ºC

[ 熔点 ]:
-5ºC

[ 分子式 ]:
C₂₂H₄₀ClN

[ 分子量 ]:
311.933

[ 闪点 ]:
>100ºC

[ 精确质量 ]:
311.237976

[ LogP ]:
7.37600

[ 外观性状 ]:
液体;Colorless to Light yellow to Light orange clear liquid

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
Miscible with water, methanol and acetone.

苯扎氯铵MSDS

详细MSDS(安全技术说明书)

苯扎氯铵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BO3151000

CHEMICAL NAME :: Ammonium, alkyl(C14-16)dimethylbenzyl-, chlorides

CAS REGISTRY NUMBER :: 63449-41-2

LAST UPDATED :: 199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Blood - hemorrhage

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 12,1593,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Blood - hemorrhage

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 12,1593,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg/13W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Kidney, Ureter, Bladder - urine volume increased Blood - changes in bone marrow (not otherwise specified)

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 12(12),61,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 850 mg/kg/30D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 9100 mg/kg/52W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - other changes Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,584,1961 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

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苯扎氯铵安全信息

[ 符号 ]:

GHS05, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H400

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C: Corrosive;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R21/22;R34;R50

[ 安全声明 (欧洲) ]:
36/37/39-45-61

[ 危险品运输编码 ]:
UN 2923

[ WGK德国 ]:
3

[ RTECS号 ]:
BO3151000

[ 包装等级 ]:
III

苯扎氯铵文献

The role of the qacA gene in mediating resistance to quaternary ammonium compounds.

Microb. Drug Resist. , (2012)

Conditions facilitating resistance to quaternary ammonium compounds (QACs) were investigated in Staphylococcus aureus SK982 exposed to benzalkonium chloride (BAC; a member of QACs) under various circu...

Assessment of susceptibility of mould isolates towards biocides.

J. Mycol. Med. 25 , 280-6, (2015)

The aim of this study was to determine the susceptibility of 77 mould strains: Aspergillus fumigatus (20), Aspergillus flavus (8), Aspergillus niger (4), Aspergillus ochraceus (2), Penicillium citrinu...

Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms.

PLoS ONE 9 , e86669, (2014)

To date there are no clear criteria to determine whether a microbe is susceptible to biocides or not. As a starting point for distinguishing between wild-type and resistant organisms, we set out to de...

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苯扎氯铵相关知识

苯扎氯铵的毒性是什么？

2022-04-04 17:27:21

苯扎氯铵（Benzalkonium chloride）CAS号为63449-41-2，化学名称为二甲基苄基烷基氯化铵，是一种季铵化合物，对细菌、酵母菌和真菌都有良好的抑菌作用。苯扎氯铵作为一种药用辅料，常用在眼用制剂中，是一种高效的抑菌防腐剂。应用在药剂中，本品低浓度有抑菌作用，高浓度用于皮肤和黏...