邻甲苯胺盐酸盐
邻甲苯胺盐酸盐用途
1.用于季胺类化合物的制备。
2.用作合成催化剂原料、溶剂、渗透剂、防水剂、橡胶硫化促进剂。
邻甲苯胺盐酸盐名称
[ CAS 号 ]:
636-21-5
[ 中文名 ]:
2-甲基苯胺 盐酸盐
[ 英文名 ]:
o-Toluidine HCl
[中文别名 ]:
[英文别名 ]:
- 2-Methylaniline hydrochloride (1:1)
- o-Toluidine Hydrochloride
- Benzenamine, 2-methyl-, hydrochloride (1:1)
- 2-Methylaniline hydrochloride
- 2-Toluidine hydrochloride
- o-Tolylamine hydrochloride
- MFCD00012959
- o-Toluidin hydrochloride
- 2-methyl-1-aminobenzene hydrochloride
- 2-Methylanilinhydrochlorid
邻甲苯胺盐酸盐物理化学性质
[ 沸点 ]:
242 °C
[ 熔点 ]:
215-217 °C(lit.)
[ 分子式 ]:
C7H10ClN
[ 分子量 ]:
143.614
[ 闪点 ]:
85ºC
[ 精确质量 ]:
143.050171
[ PSA ]:
26.02000
[ LogP ]:
2.96040
[ 外观性状 ]:
白色结晶固体
[ 储存条件 ]:
室温
[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, alkalies. Light and moisture sensitive.
邻甲苯胺盐酸盐MSDS
邻甲苯胺盐酸盐毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XU7350000
- CHEMICAL NAME :
- o-Toluidine, hydrochloride
- CAS REGISTRY NUMBER :
- 636-21-5
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 39
- MOLECULAR FORMULA :
- C7-H9-N.Cl-H
- MOLECULAR WEIGHT :
- 143.63
- WISWESSER LINE NOTATION :
- ZR B1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2951 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 113 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27300 mg/kg/13W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 54600 mg/kg/26W-C
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 117 gm/kg/101W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 146 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 159 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Vascular - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 262 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 125 gm/kg/73W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Blood - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1210 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 233 gm/kg/101W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2142 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12936 gm/kg/77W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2121 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4242 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12936 gm/kg/77W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - tumors
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 750 mg/L
- REFERENCE :
- TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 2,103,1988 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,155,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8305 No. of Facilities: 32 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 355 (estimated)
邻甲苯胺盐酸盐安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H312 + H332-H350
[ 警示性声明 ]:
P201-P280-P308 + P313
[ 个人防护装备 ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T: Toxic;
[ 风险声明 (欧洲) ]:
R45
[ 安全声明 (欧洲) ]:
S53-S36/37/39-S45
[ 危险品运输编码 ]:
UN 2811 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
XU735000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1(a)
[ 海关编码 ]:
2921430090
邻甲苯胺盐酸盐合成路线
邻甲苯胺盐酸盐制备
1.由乙醇和氨在氢气和铜- 镍- 白土催化剂存在下反应而得：
用盐酸酸化成盐，然后在乙醇中重结晶精制，再与碱作用分出有机相，经精馏得纯品。
邻甲苯胺盐酸盐海关
[ 海关编码 ]: 2921430090
[ 中文概述 ]:
2921430090 甲苯胺及其衍生物以及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 原产地证据文件及编号(例 附原产地证书, 原产于欧盟的
[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
邻甲苯胺盐酸盐文献
Rapid Commun. Mass Spectrom. 26(23) , 2770-6, (2012)
Desorption electrospray ionization (DESI) is the most popular ambient ionization technique for direct analysis of complex samples without sample pretreatment. However, for many applications, especiall...
Exposure to o-toluidine, aniline, and nitrobenzene in a rubber chemical manufacturing plant: a retrospective exposure assessment update.J. Occup. Environ. Hyg. 9(8) , 478-90, (2012)
The National Institute for Occupational Safety and Health previously conducted a retrospective cancer incidence and mortality study of workers employed at a rubber chemical manufacturing plant. Compar...
Exposure of hairdressers to ortho- and meta-toluidine in hair dyes.Occup. Environ. Med. 72(1) , 57-63, (2015)
Carcinogenic aromatic amines derived from hair dyes have recently received new attention. One of these is ortho (o)-toluidine, which is classified as carcinogenic to humans.To clarify exposure of hair...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：邻联甲苯胺盐酸盐
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥2871.0/500g
￥834.0/100g
￥261.0/25g
￥112.0/5g
联系人：夏言
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥69.9/5g
￥799.9/100g
￥219.9/25g
￥需询单/5g
联系人：阿拉丁
产品详情：邻甲苯胺盐酸盐
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相关化合物
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