他利霉素
他利霉素名称
[ CAS 号 ]:
65057-90-1
[ 中文名 ]:
他利霉素
[ 英文名 ]:
Bleomycinamide,N1-[4-amino-6-[[3-[(4-aminobutyl)amino]propyl]amino]-6-oxohexyl]-13-[(4-amino-4,6-dideoxy-a-L-talopyranosyl)oxy]-19-demethyl-12-hydroxy-
[英文别名 ]:
- Antibiotic BU-2231A
- Tallysomycin A
- Bu-2231A
他利霉素物理化学性质
[ 密度 ]:
1.58g/cm3
[ 分子式 ]:
C68H110N22O27S2
[ 分子量 ]:
1731.86000
[ 精确质量 ]:
1730.74000
[ PSA ]:
881.89000
[ 折射率 ]:
1.686
他利霉素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EC5990300
- CHEMICAL NAME :
- Bleomycinamide, N(sup 1)-(4-amino-6-((3-((4-aminobutyl)amino)propyl)amino)- 6-oxohexyl)- 13-((4-amino-4,6-dideoxy-alpha-L-talopyranosyl)oxy)-1 9-demethyl-12-hydroxy-
- CAS REGISTRY NUMBER :
- 65057-90-1
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C68-H110-N22-O27-S2
- MOLECULAR WEIGHT :
- 1732.12
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 17 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg/4W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - fibrosis (interstitial)
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 100 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,288,1983
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