1,10-菲罗啉

1,10-菲罗啉用途

o-Phenanthroline (1,10-Phenanthroline) 是一种金属螯合剂,可防止链脲佐菌素诱导染色体畸变。o-Phenanthroline (1,10-Phenanthroline)与Fe2+形成红色螯合物,在510 nm处最大吸收。

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1,10-菲罗啉名称

[ CAS 号 ]:
66-71-7

[ 中文名 ]:
1,10-菲罗啉

[ 英文名 ]:
1,10-Phenanthroline

[中文别名 ]:

[英文别名 ]:

1,10-Phenanthroline
4,5-Diazaphenanthrene
4,5-Phenanthroline
ORTHOPHENANTHROLINE
EINECS 200-629-2
1,10-o-Phenanthroline
o-Phenanthroline
β-Phenanthroline
1,10-Fenanthroline
phenanthroline

1,10-菲罗啉生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Guan NanMu, et al. Synergistic inhibition between o-phenanthroline and chloride ion on cold rolled steel corrosion in phosphoric acid. Materials Chemistry and Physics Volume 86, Issue 1, 15 July 2004, Pages 59-68.

1,10-菲罗啉物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
365.1±15.0 °C at 760 mmHg

[ 熔点 ]:
114-117 °C(lit.)

[ 分子式 ]:
C₁₂H₈N₂

[ 分子量 ]:
180.205

[ 闪点 ]:
164.8±11.7 °C

[ 精确质量 ]:
180.068741

[ PSA ]:
25.78000

[ LogP ]:
1.78

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.740

[ 储存条件 ]:
Refrigerator

[ 稳定性 ]:
Stable. Hygroscopic. Store under nitrogen. Incompatible with strong acids, strong oxidizing agents.

[ 水溶解性 ]:
slightly soluble

1,10-菲罗啉MSDS

1,10-菲罗啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF8300000

CHEMICAL NAME :: 1,10-Phenanthroline

CAS REGISTRY NUMBER :: 66-71-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H8-N2

MOLECULAR WEIGHT :: 180.22

WISWESSER LINE NOTATION :: T B666 CN NNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 5 mg/L

REFERENCE :: ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 46,193,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82276 No. of Facilities: 1002 (estimated) No. of Industries: 12 No. of Occupations: 11 No. of Employees: 8324 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82276 No. of Facilities: 2265 (estimated) No. of Industries: 33 No. of Occupations: 35 No. of Employees: 40330 (estimated) No. of Female Employees: 2577 (estimated)

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1,10-菲罗啉安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H410

[ 警示性声明 ]:
P273-P301 + P310-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25;R50/53

[ 安全声明 (欧洲) ]:
S45-S60-S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SF8437000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29339990

1,10-菲罗啉合成路线

1,10-菲罗啉上下游产品

1,10-菲罗啉上游产品

1,10-菲罗啉下游产品

1,10-菲罗啉制备

1.将邻苯二胺与甘油、硝基苯及浓硫酸一起加热，或改用8-氨基喹啉为原料，都可制备该品。

2.将８氨基喹啉、丙三醇和五氧化二砷，搅拌均匀并加入浓硫酸，反应混合物倒入水中，用冷氨水中和，
用沸腾的苯萃取黑色稠状物，经处理即可。

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1,10-菲罗啉海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,10-菲罗啉文献

Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution.

Proc. Natl. Acad. Sci. U. S. A. 112(11) , E1181-90, (2015)

Agonist binding to G-protein-coupled receptors (GPCRs) triggers signal transduction cascades involving heterotrimeric G proteins as key players. A major obstacle for drug design is the limited knowled...

Essential Oil from Clove Bud (Eugenia aromatica Kuntze) Inhibit Key Enzymes Relevant to the Management of Type-2 Diabetes and Some Pro-oxidant Induced Lipid Peroxidation in Rats Pancreas in vitro.

J. Oleo Sci. 64 , 775-82, (2015)

The inhibition of enzymes involved in the breakdown of carbohydrates is considered a therapeutic approach to the management of type-2 diabetes. This study sought to investigate the effects of essentia...

Monitoring the inorganic chemical reaction by surface-enhanced Raman spectroscopy: A case of Fe³⁺ to Fe²⁺ conversion.

Talanta 146 , 452-6, (2015)

Monitoring the process of organic chemical reactions to study the kinetics by surface-enhanced Raman spectroscopy (SERS) is currently of immense interest. However, monitoring the inorganic chemical re...

更多文献

1,10-菲罗啉

1,10-菲罗啉用途

1,10-菲罗啉名称

1,10-菲罗啉生物活性

1,10-菲罗啉物理化学性质

1,10-菲罗啉MSDS

详细MSDS(安全技术说明书)

1,10-菲罗啉毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,10-菲罗啉安全信息

1,10-菲罗啉合成路线

详细合成路线

1,10-菲罗啉上下游产品

1,10-菲罗啉上游产品

1,10-菲罗啉下游产品

1,10-菲罗啉制备

1,10-菲罗啉海关

1,10-菲罗啉文献

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