1-(4-甲基苯基)-3-氮杂双环[3.1.0]己烷盐酸盐

用途

Bicifadine HCl, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad-spectrum monoamine transporter inhibitor or "triple reuptake inhibitor."

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名称

[ CAS 号 ]:
66504-75-4

[ 中文名 ]:
1-(4-甲基苯基)-3-氮杂双环[3.1.0]己烷盐酸盐

[ 英文名 ]:
Bicifadine hydrochloride

[英文别名 ]:

bicifadine

物理化学性质

[ 分子式 ]:
C₁₂H₁₅N

[ 分子量 ]:
173.25400

[ 精确质量 ]:
173.12000

[ PSA ]:
12.03000

[ LogP ]:
2.18470

安全信息

[ 海关编码 ]:
2933990090

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海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%