恩舒尼盐酸盐

恩舒尼盐酸盐用途

盐酸恩卡肽(MJ9067)是一种具有IC类活性的抗心律失常药物。Encainide有可能用于威胁生命的室性心律失常、症状性室性心律失常和室上性心律失常的研究[1]。
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恩舒尼盐酸盐名称

[ CAS 号 ]:
66794-74-9

[ 中文名 ]:
恩卡尼盐酸盐

[ 英文名 ]:
Encainide hydrochloride

[英文别名 ]:

恩舒尼盐酸盐生物活性

[ 描述 ]:

盐酸恩卡肽(MJ9067)是一种具有IC类活性的抗心律失常药物。Encainide有可能用于威胁生命的室性心律失常、症状性室性心律失常和室上性心律失常的研究[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> 其他 >> 其他

[体内研究]

盐酸恩卡肽(MJ9067盐酸盐；0.3,0.9,2.7 mg/kg；单剂量输注)可延长其浦肯野传导时间(HV间期)和心室内传导时间(QRS持续时间),但对窦房结恢复时间或房室结传导,或对心房、房室结的难治性无影响,或心室肌或QT间期[1]。

[参考文献]

[1]. R N Brogden, et al. Encainide. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1987 Nov;34(5):519-38.

恩舒尼盐酸盐物理化学性质

[ 密度 ]:
1.106g/cm3

[ 沸点 ]:
439.9ºC at 760mmHg

[ 分子式 ]:
C22H29ClN2O2

[ 分子量 ]:
388.93100

[ 闪点 ]:
219.8ºC

[ 精确质量 ]:
388.19200

[ PSA ]:
41.57000

[ LogP ]:
5.17730

[ 外观性状 ]:
粉末

[ 储存条件 ]:
2-8°C

恩舒尼盐酸盐MSDS

详细MSDS(安全技术说明书)

恩舒尼盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV5521500
CHEMICAL NAME :
Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)pheny l)-, monohydrochloride, (+-)-
CAS REGISTRY NUMBER :
66794-74-9
LAST UPDATED :
199604
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C22-H28-N2-O2.Cl-H
MOLECULAR WEIGHT :
388.98

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
57 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,93,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
86 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,93,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,93,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,93,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,93,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,93,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,93,1983
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恩舒尼盐酸盐安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25-36/37/38

[ 安全声明 (欧洲) ]:
26-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
CV5521500

恩舒尼盐酸盐文献

Encainide hydrochloride and flecainide acetate: two class 1c antiarrhythmic agents.

Clin. Pharm. 6(11) , 839-50, (1987)

The chemistry, electrophysiology, pharmacokinetics, clinical use and efficacy, adverse effects, drug interactions, and dosage of encainide hydrochloride and flecainide acetate are reviewed. Encainide ...

ST segment elevation induced by class IC antiarrhythmic agents: underlying electrophysiologic mechanisms and insights into drug-induced proarrhythmia.

J. Cardiovasc. Electrophysiol. 9(11) , 1167-72, (1998)

Three patients in whom Class IC sodium channel blockers induced ST segment elevation in leads V1 through V3 are described. The underlying electrophysiologic mechanism, implications for drug-induced pr...

Adherence and arrhythmic mortality in the cardiac arrhythmia suppression trial (CAST).

Ann. Epidemiol. 6(2) , 93-101, (1996)

Patient adherence to therapy is essential to assess treatment efficacy, particularly in clinical trials. Active treatment usually is expected to benefit patients. The healthy adherer effect, the assoc...


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