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苯丙氨酯

苯丙氨酯用途

苯丙氨酯(3-苯基丙基氨基甲酸酯；MH 532；普罗福米芬)是一种广泛使用的中枢作用骨骼肌松弛剂,具有镇静和抗惊厥作用[1]。

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苯丙氨酯名称

[ CAS 号 ]:
673-31-4

[ 中文名 ]:
苯丙氨酯

[ 英文名 ]:
phenprobamate

[中文别名 ]:

[英文别名 ]:

Quamaquil
Extacol
Proformiphen
Carbamic Acid 3-Phenylpropyl Ester
phenprobamate
Nelaxan
3-Phenylpropyl carbamate
Gamaquil
EINECS 211-606-1
MFCD00868163

苯丙氨酯生物活性

[ 描述 ]:

苯丙氨酯(3-苯基丙基氨基甲酸酯；MH 532；普罗福米芬)是一种广泛使用的中枢作用骨骼肌松弛剂,具有镇静和抗惊厥作用[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. J X Sun, et al. High-performance liquid chromatographic analysis, plasma protein binding and red blood cell partitioning of phenprobamate. Biopharm Drug Dispos. Jul-Aug 1987;8(4):341-51.

苯丙氨酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
295.5±33.0 °C at 760 mmHg

[ 熔点 ]:
101-104℃

[ 分子式 ]:
C₁₀H₁₃NO₂

[ 分子量 ]:
179.216

[ 闪点 ]:
132.5±25.4 °C

[ 精确质量 ]:
179.094635

[ PSA ]:
52.32000

[ LogP ]:
2.16

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.519

[ 储存条件 ]:
室温

苯丙氨酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB9275000

CHEMICAL NAME :: 1-Propanol, 3-phenyl-, carbamate

CAS REGISTRY NUMBER :: 673-31-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H13-N-O2

MOLECULAR WEIGHT :: 179.24

WISWESSER LINE NOTATION :: ZVO3R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1110 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,856,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,140,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,340,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,1047,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

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苯丙氨酯安全信息

[ 海关编码 ]:
2924299090

苯丙氨酯合成路线

详细合成路线

苯丙氨酯上下游产品

苯丙氨酯上游产品

苯丙氨酯下游产品

苯丙氨酯制备

【方法一】
由3-苯丙醇与氰酸钠缩合、水解而得。将无水甲苯、3-苯丙醇及氰酸钠加入反应罐中，冷至10℃，搅拌下导入氯化氢气体，约80min，温度上升至55℃后开始下降。通气毕，在55-60℃反应0.5h。冷至30℃，加入氨水升温至70℃，静置0.5h，分取有机层，过滤，滤液冷却结晶。过滤，结晶用甲苯洗涤，再用蒸馏水洗至氯根符合要求止。气流干燥，得苯丙氨酯。

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苯丙氨酯海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

苯丙氨酯

苯丙氨酯用途

苯丙氨酯名称

苯丙氨酯生物活性

苯丙氨酯物理化学性质

苯丙氨酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

苯丙氨酯安全信息

苯丙氨酯合成路线

详细合成路线

苯丙氨酯上下游产品

苯丙氨酯上游产品

苯丙氨酯下游产品

苯丙氨酯制备

苯丙氨酯海关

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