glycoprotein 3-α-L-fucosyltransferase

需要Mn2+。该酶转移到N-连接的低聚糖结构(N-聚糖),通常对带有一个未取代的非还原末端GlcNAc残基的N-聚糖具有特异性。这种酶催化的反应类似于酶代码EC2.4.1.68,糖蛋白6-α-L-岩藻糖基转移酶,但将L-岩藻糖基从GDP-β-L-岩藻糖转移到形成α1,3-键而不是α1,6-键。这种酶的N-聚糖产物存在于植物、昆虫和一些其他无脊椎动物(如血吸虫、血吸虫、淋菌)中。 反应：GDP-β-L-fucose + N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-[α-L-fucosyl-(1→3)]-N-acetyl-β-D-glucosaminyl}asparagine