(±)-己酰肉碱氯化物

(±)-己酰肉碱氯化物用途

(±)-氯化六酰基肉碱是一种脂肪酸代谢产物,可将脂肪酸分解为可供身体使用的能量。(±)-氯化六酰基肉碱也是大鼠骨骼肌毒性的一种特异且易于检测的生物标志物。在对股直肌的代谢组学分析中,赛伐他汀(HY-129458)和TMPD(HY-W012145)诱导大鼠中六酰基肉碱的增加。在2型糖尿病中,六酰基肉碱也与全因死亡率显著相关,并可改善全因死亡率的预测。六酰基肉碱是鉴定新致病途径的生物标志物[1][2]。

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(±)-己酰肉碱氯化物名称

[ CAS 号 ]:
6920-35-0

[ 中文名 ]:
(±)-己酰肉碱氯化物

[ 英文名 ]:
(±)-Hexanoylcarnitine chloride

[英文别名 ]:

Ruthenium Red
DL-Hexanoylcarnitine chloride
DL-Caproylcarnitine chloride

(±)-己酰肉碱氯化物生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. Scarale MG, et al. Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes. Diabetes. 2022 Jun 1;71(6):1363-1370.

[2]. Obayashi H, et al. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. J Toxicol Sci. 2017;42(4):385-396.

(±)-己酰肉碱氯化物物理化学性质

[ 分子式 ]:
C₁₃H₂₆ClNO₄

[ 分子量 ]:
295.80

[ 精确质量 ]:
295.15500

[ PSA ]:
63.60000

(±)-己酰肉碱氯化物安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-43

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2923900090

(±)-己酰肉碱氯化物海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

(±)-己酰肉碱氯化物文献

Production of acyl-carnitines from the metabolism of [U-14C]3-methyl-2-oxopentanoate by rat liver and skeletal muscle mitochondria.

Clin. Invest. Med. 18(2) , 144-51, (1995)

A sensitive method of continuous on-line radio-high performance liquid chromatography (HPLC) was used to detect the specific radio-labelled acyl-carnitine esters derived from the oxidation of [U-14C]3...

Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle.

Pediatr. Res. 52(1) , 64-70, (2002)

Defects of mitochondrial fatty acid beta-oxidation are an important group of inherited metabolic disorders in children. Despite improved screening opportunities, diagnosis of these disorders is not of...

Metabolomics identifies perturbations in human disorders of propionate metabolism.

Clin. Chem. 53(12) , 2169-76, (2007)

We applied untargeted mass spectrometry-based metabolomics to the diseases methylmalonic acidemia (MMA) and propionic acidemia (PA).We used a screening platform that used untargeted, mass-based metabo...

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