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丙位己内酯

丙位己内酯用途

γ-Hexalactone 是存在成熟水果中的一种 gamma 内酯。γ-Hexalactone 能引起 DNA 损伤,可作为对氧磷酶 1 的底物 (PON1)。

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丙位己内酯名称

[ CAS 号 ]:
695-06-7

[ 中文名 ]:
γ-己内酯

[ 英文名 ]:
γ-Caprolactone

[中文别名 ]:

[英文别名 ]:

4-Hexanolide
γ-Ethyl-γ-butyrolactone
gamma-Hexanolactone
5-Ethyldihydrofuran-2(3H)-one
gamma-caprolactone
5-Ethyldihydrofuran-2(3H)-on
2(3H)-Furanone, 5-ethyldihydro-
5-Ethyldihydro-2(3H)-furanone
MFCD00005401
g-Caprolactone

丙位己内酯生物活性

[ 描述 ]:

γ-Hexalactone 是存在成熟水果中的一种 gamma 内酯。γ-Hexalactone 能引起 DNA 损伤,可作为对氧磷酶 1 的底物 (PON1)。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. E-Nose and GC-MS Reveal a Difference in the Volatile Profiles of White- and Red-Fleshed Peach Fruit. Sensors (Basel). 2018 Mar 2;18(3).

[2]. Bianchi T, et al. Investigation of the aroma of commercial peach (Prunus persica L. Batsch) types by Proton Transfer Reaction-Mass Spectrometry (PTR-MS) and sensory analysis. Food Res Int. 2017 Sep;99(Pt 1):133-146.

[3]. Shangula S, et al. PON1 increases cellular DNA damage by lactone substrates. Arch Toxicol. 2019 Jul;93(7):2035-2043.

丙位己内酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
214.9±8.0 °C at 760 mmHg

[ 熔点 ]:
-18°C

[ 分子式 ]:
C₆H₁₀O₂

[ 分子量 ]:
114.142

[ 闪点 ]:
98.3±0.0 °C

[ 精确质量 ]:
114.068077

[ PSA ]:
26.30000

[ LogP ]:
0.26

[ 外观性状 ]:
无色至淡黄色液体带有一种草本的,甜的气味

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.432

[ 储存条件 ]:
室温

丙位己内酯MSDS

丙位己内酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU4220000

CHEMICAL NAME :: 2(3H)-Furanone, 5-ethyldihydro-

CAS REGISTRY NUMBER :: 695-06-7

BEILSTEIN REFERENCE NO. :: 0107260

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H10-O2

MOLECULAR WEIGHT :: 114.16

WISWESSER LINE NOTATION :: T5OVTJ E2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,791,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,794,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,794,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6862 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

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丙位己内酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LU4220000

[ 海关编码 ]:
2932209090

丙位己内酯合成路线

丙位己内酯上下游产品

丙位己内酯上游产品

丙位己内酯下游产品

丙位己内酯制备

1. 由环氧乙烷与钠代丙二酸酯反应而得。

2. 烟草：BU，56；BU，14；FC，9， 18；BU，18。用二氯化锡、浓盐酸在85ºC下乙酸溶液中还原山梨酸而得。

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丙位己内酯海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

丙位己内酯文献

Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.

J. Med. Chem. 48 , 3808-15, (2005)

The purpose of this study was to determine the cytochrome P450 1A2 (CYP1A2) inhibition potencies of structurally diverse compounds to create a comprehensive three-dimensional quantitative structure-ac...

Profile of volatile metabolites in human urine.

Clin. Chem. 17(7) , 592-4, (1971)

The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells.

Biomaterials 30 , 4287-96, (2009)

The potential of mesenchymal stem cells (MSCs) as a viable cell source for cartilage repair hinges on the development of engineered scaffolds that support adequate cartilage tissue formation. Evolving...

更多文献

丙位己内酯

丙位己内酯用途

丙位己内酯名称

丙位己内酯生物活性

丙位己内酯物理化学性质

丙位己内酯MSDS

详细MSDS(安全技术说明书)

丙位己内酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

丙位己内酯安全信息

丙位己内酯合成路线

详细合成路线

丙位己内酯上下游产品

丙位己内酯上游产品

丙位己内酯下游产品

丙位己内酯制备

丙位己内酯海关

丙位己内酯文献

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