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H-Phe-Leu-Glu-Glu-Leu-OH

H-Phe-Leu-Glu-Glu-Leu-OH用途

H-Phe-Leu-Glu-Glu-Leu-OH是一种合成的五肽,可作为维生素K依赖性羧化酶的底物,生成的产物中的谷氨酰残基被羧化[1][2]。

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H-Phe-Leu-Glu-Glu-Leu-OH名称

[ CAS 号 ]:
69729-06-2

[ 英文名 ]:
H-Phe-Leu-Glu-Glu-Leu-OH

[英文别名 ]:

PHE-LEU-GLU-GLU-LEU
FLEEL
phenylalanine-leucine-glutamine-glutamine-leucine
MFCD00076877

H-Phe-Leu-Glu-Glu-Leu-OH生物活性

[ 描述 ]:

H-Phe-Leu-Glu-Glu-Leu-OH是一种合成的五肽,可作为维生素K依赖性羧化酶的底物,生成的产物中的谷氨酰残基被羧化[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Rich DH, et al. Synthesis of peptide analogues of prothrombin precursor sequence 5-9. Substrate specificity of vitamin K dependent carboxylase. J Med Chem. 1981 Jun;24(6):706-11.

[2]. Rich DH, et al. Synthesis and biological properties of new hexapeptide substrates for vitamin K dependent carboxylase. Evidence for X-Pro cis/trans amide bond interconversions in prothrombin precursor fragment 18-23. J Med Chem. 1983 Jun;26(6):910-6.

H-Phe-Leu-Glu-Glu-Leu-OH物理化学性质

[ 密度 ]:
1.259g/cm3

[ 沸点 ]:
1059.8ºC at 760 mmHg

[ 分子式 ]:
C₃₁H₄₇N₅O₁₀

[ 分子量 ]:
649.73

[ 闪点 ]:
594.8ºC

[ 精确质量 ]:
649.33200

[ PSA ]:
254.32000

[ LogP ]:
2.66590

[ 折射率 ]:
1.551

H-Phe-Leu-Glu-Glu-Leu-OH安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

H-Phe-Leu-Glu-Glu-Leu-OH文献

Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile.

Eur. J. Biochem. 269 , 6162-6172, (2002)

The marine snail Conus is the sole invertebrate wherein both the vitamin K-dependent carboxylase and its product, gamma-carboxyglutamic acid, have been identified. To examine its biosynthesis of gamma...

Isolation and partial characterization of a vitamin K-dependent carboxylase from bovine aortae.

Biochem. J. 245 , 251-255, (1987)

Vitamin K-dependent carboxylase activity has been demonstrated in the crude microsomal fraction of the intima of bovine aortae. The procedure for the isolation of vessel wall carboxylase is a slight m...

Vitamin K-dependent carboxylase: purification of the rat liver microsomal enzyme.

Arch. Biochem. Biophys. 202 , 515, (1980)

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