Rachelmycin
Rachelmycin用途
Rachelmycin (CC-1065; NSC 298223) 是一种从 Streptomyces zelensis 中分离得到有效的天然抗生素 (antibiotic)。Rachelmycin 在 B 型 DNA 的小沟中非共价和共价结合 (N-3 腺嘌呤加合物)。Rachelmycin 具有极强的抗肿瘤活性。
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Rachelmycin名称
Rachelmycin生物活性
[ 描述 ]:
Rachelmycin (CC-1065; NSC 298223) 是一种从 Streptomyces zelensis 中分离得到有效的天然抗生素 (antibiotic)。Rachelmycin 在 B 型 DNA 的小沟中非共价和共价结合 (N-3 腺嘌呤加合物)。Rachelmycin 具有极强的抗肿瘤活性。
[ 相关类别 ]:
[体内研究]
在对非肿瘤性BDF1小鼠的实验中,发生延迟死亡的最小剂量为拉赫霉素(CC-1065；NSC 298223；12.5 mg/kg)[1]。
[参考文献]
Rachelmycin物理化学性质
[ 密度 ]:
1.75g/cm3
[ 分子式 ]:
C37H33N7O8
[ 分子量 ]:
703.70000
[ 精确质量 ]:
703.23900
[ PSA ]:
210.31000
[ LogP ]:
4.62030
[ 折射率 ]:
1.878
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放
Rachelmycin毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DF4936700
- CAS REGISTRY NUMBER :
- 69866-21-3
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C37-H33-N7-O8
- MOLECULAR WEIGHT :
- 703.77
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >8800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6900 ng/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 ug/kg
- TOXIC EFFECTS :
- Liver - fatty liver degeneration
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 7400 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,999,1982 *** REVIEWS *** TOXICOLOGY REVIEW JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 39,319,1986
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Rachelmycin合成路线
Rachelmycin上下游产品
Rachelmycin上游产品
Rachelmycin下游产品
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