(S)-(+)-4-氨基-3-羟基丁酸

(S)-(+)-4-氨基-3-羟基丁酸用途

GABOB, also known as γ-Amino-β-hydroxybutyric acid, β-hydroxy-γ-aminobutyric acid, β-hydroxy-GABA, is an anticonvulsant which is used for the treatment of epilepsy in Europe, Japan, and Mexico. It is also an endogenous active metabolite and analogue of the neurotransmitter γ-aminobutyric acid (GABA), and for this reason, may function as a neurotransmitter itself.

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(S)-(+)-4-氨基-3-羟基丁酸名称

[ CAS 号 ]:
7013-05-0

[ 中文名 ]:
(S)-(+)-4-氨基-3-羟基丁酸

[ 英文名 ]:
(S)-(+)-4-Amino-3-hydroxybutyric acid

[英文别名 ]:

3-Hydroxy-4-aminobutyric acid
γ-amino-β-hydroxybutyric acid
(S)-4-AMINO-3-HYDROXYBUTANOIC ACID
3-hydroxy-4-amino-butyric acid (GABOB)
3-hydroxy-GABA
β-Hydroxy-GABA
3-hydroxy-4-amino-butyric acid
Butanoic acid, 4-amino-3-hydroxy-
(S)-(+)-GABOB
acide (S)-amino-4 hydroxy-3 butanoique

(S)-(+)-4-氨基-3-羟基丁酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
374.5±32.0 °C at 760 mmHg

[ 熔点 ]:
207-212ºC

[ 分子式 ]:
C₄H₉NO₃

[ 分子量 ]:
119.119

[ 闪点 ]:
180.3±25.1 °C

[ 精确质量 ]:
119.058243

[ PSA ]:
83.55000

[ LogP ]:
-1.73

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.511

[ 储存条件 ]:
室温，避光，保存于惰性气体中

(S)-(+)-4-氨基-3-羟基丁酸MSDS

详细MSDS(安全技术说明书)

(S)-(+)-4-氨基-3-羟基丁酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

(S)-(+)-4-氨基-3-羟基丁酸合成路线

详细合成路线

(S)-(+)-4-氨基-3-羟基丁酸上下游产品

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(S)-(+)-4-氨基-3-羟基丁酸下游产品

(S)-(+)-4-氨基-3-羟基丁酸文献

Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.

Bioorg. Med. Chem. Lett. 18 , 402-4, (2008)

The R- and S-enantiomers of 4-amino-3-hydroxybutanoic acid (GABOB) were full agonists at human recombinant rho1 GABA(C) receptors. Their enantioselectivity (R>S) matched that reported for their agonis...

GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.

J. Med. Chem. 28(11) , 1612-7, (1985)

(RS)-5-(Aminomethyl)-2-isoxazolin-3-ol (dihydromuscimol, DHM) is a potent 4-aminobutyric acid (GABA) agonist, the inhibitory effects of which on neurons are sensitive to the antagonist bicuculline met...

Formation of gamma-amino-beta-hydroxybutyric acid from 2-hydroxyputrescine in rat brain.

J. Neurochem. 51(2) , 548-51, (1988)

gamma-Amino-beta-[3H]hydroxybutyric acid ([3H]-GABOB) was formed in rat brain from 2-[3H]-hydroxyputrescine that had been chemically synthesized from 2-oxoputrescine and [3H]sodium borohydride. After ...

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