哌莫硝唑

哌莫硝唑用途

Pimonidazole 哌莫硝唑是一种缺氧标记物,用于瘤内缺氧和细胞增殖的补充性研究。Pimonidazole 静脉给药后进行活组织检查,可用于定性和定量评估肿瘤缺氧。Pimonidazole 通过与大分子的共价结合或通过被还原形成还原性代谢物后在缺氧细胞中积累。

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哌莫硝唑名称

[ CAS 号 ]:
70132-50-2

[ 中文名 ]:
哌莫硝唑

[ 英文名 ]:
Pimonidazole

[英文别名 ]:

Pimonidazol
UNII:46JO4D76R2
Pimonidazole [INN:BAN]
Pimonidazole
Pimonidazol [Spanish]
Pimonidazolum
Ro 03-8799
Pimonidazolum [Latin]

哌莫硝唑生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7.

[2]. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639.

哌莫硝唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
490.5±55.0 °C at 760 mmHg

[ 分子式 ]:
C₁₁H₁₈N₄O₃

[ 分子量 ]:
254.286

[ 闪点 ]:
250.5±31.5 °C

[ 精确质量 ]:
254.137894

[ PSA ]:
87.11000

[ LogP ]:
1.00

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.642

[ 储存条件 ]:
2-8°C

哌莫硝唑MSDS

哌莫硝唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

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哌莫硝唑文献

Loss of the Notch effector RBPJ promotes tumorigenesis.

J. Exp. Med. 212(1) , 37-52, (2015)

Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation ...

Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension.

Microcirculation 22 , 724-736, (2016)

Myocardial angiogenesis is presumed to play a role in RV adaptation to PH, though definitive evidence and functional correlations are lacking. We aimed to use definitive methods to correlate RV angiog...

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling.

Oncotarget 5(20) , 9664-77, (2014)

Hypoxia is a common phenomenon occurring in the majority of human tumors and has been proved to play an important role in tumor progression. However, it remains unclear that whether the action of hypo...

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