1,2-二乙酰苯

[ 密度 ]:
110 C 0.1 mm Hg(lit.)

[ 沸点 ]:
110 °C0.1 mm Hg(lit.)

[ 熔点 ]:
39-41 °C(lit.)

[ 分子式 ]:
C₁₀H₁₀O₂

[ 分子量 ]:
162.18500

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
162.06800

[ PSA ]:
34.14000

[ LogP ]:
2.09180

[ 外观性状 ]:
白色至淡的黄色粉末

[ 折射率 ]:
1.519

[ 储存条件 ]:
2-8°C

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KM5782637

CHEMICAL NAME :

Ethanone, 1,1'-(1,2-phenylene)bis-

CAS REGISTRY NUMBER :

704-00-7

LAST UPDATED :

199606

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C10-H10-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

440 mg/kg/11W-I

TOXIC EFFECTS :

Peripheral Nerve and Sensation - recording from afferent nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve

REFERENCE :

JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 11,261,1991

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

320 mg/kg/8W-I

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :

JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 12,343,1992

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
KM5782637

[ 海关编码 ]:
29143900

详细合成路线

1,2-二乙酰苯上游产品

1,2-二乙酰苯下游产品

[ 海关编码 ]: 29143900

New insights into mechanisms of gamma-diketone-induced axonopathy.

Neurochem. Res. 34(11) , 1919-23, (2009)

We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-f...

Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport.

Neurochem. Res. 32(12) , 2152-9, (2007)

The aromatic hydrocarbon 1,2-diacetylbenzene (1,2-DAB) is a protein-reactive gamma-diketone metabolite of the neurotoxic solvent 1,2-diethylbenzene (1,2-DEB). The effect of neurotoxic 1,2-DAB and its ...

Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy.

Toxicol. Appl. Pharmacol. 183(1) , 55-65, (2002)

The gamma-diketone analogs 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD), but not the delta-diketone 1,3-diacetylbenzene (1,3-DAB) or the beta-diketone 2,4-hexanedione, induce neuropathol...

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