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多聚[2,8-(N-乙酰基神经氨酸钠)]

多聚[2,8-(N-乙酰基神经氨酸钠)]用途

Colominic acid sodium salt (Polysialic acid sodium salt) 可从大肠杆菌的细胞壁或者动物中天然提取到,其吸收波长是 530 nm,发红光,具有抗菌活性。

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多聚[2,8-(N-乙酰基神经氨酸钠)]名称

[ CAS 号 ]:
70431-34-4

[ 中文名 ]:
多聚[2,8-(N-乙酰基神经氨酸钠)]

[ 英文名 ]:
Colominic acid sodium salt

[中文别名 ]:

多聚唾液酸钠盐

[英文别名 ]:

Colominic acid sodium salt from Escherichia coli
MFCD00133197

多聚[2,8-(N-乙酰基神经氨酸钠)]生物活性

[ 描述 ]:

Colominic acid sodium salt (Polysialic acid sodium salt) 可从大肠杆菌的细胞壁或者动物中天然提取到,其吸收波长是 530 nm,发红光,具有抗菌活性。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

[体外研究]

Colominic acid(Polysialic acid)是N-糖基化的一种形式,对其有限的中枢神经系统靶点具有很强的特异性,包括细胞粘附分子、神经细胞粘附分子(NCAM)和突触细胞粘附分子1(SynCAM1)和受体神经肽-2[2]。

[参考文献]

[1]. Guy T. Barry, et al. COLOMINIC ACID, A POLYMER OF N-ACETYLNEURAMINIC ACID. J Exp Med. 1958 Apr 1;107(4):507-21.

[2]. Osama I Alwassil, et al. Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection. PLoS One. 2019 Oct 16;14(10):e0223413.

多聚[2,8-(N-乙酰基神经氨酸钠)]物理化学性质

[ 分子式 ]:
C₃₃H₄₈N₃Na₃O₂₅

[ 分子量 ]:
955.70900

[ 精确质量 ]:
955.22700

[ PSA ]:
454.37000

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
-20°C

多聚[2,8-(N-乙酰基神经氨酸钠)]安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

多聚[2,8-(N-乙酰基神经氨酸钠)]文献

An IgG monoclonal antibody to group B meningococci cross-reacts with developmentally regulated polysialic acid units of glycoproteins in neural and extraneural tissues.

J. Immunol. 138 , 4402-4407, (1987)

The structurally similar polysialic acid capsules of group B meningococci and Escherichia coli K1 are poor immunogens, and attempts are currently being made to improve their immunogenicity by chemical...

Polysialic acid units are spatially and temporally expressed in developing postnatal rat kidney.

Proc. Natl. Acad. Sci. U. S. A. 84 , 1969-1973, (1987)

We report the presence of alpha(2----8)-linked polysialic acid as detected with a monoclonal antibody outside the nervous tissue in the postnatal developing rat kidney. By immunoblot analysis, the rea...

Reexpression of poly(sialic acid) units of the neural cell adhesion molecule in Wilms tumor.

Proc. Natl. Acad. Sci. U. S. A. 85 , 2999-3003, (1988)

A unique structural feature of the neural cell adhesion molecule N-CAM is the presence of homopolymers of alpha (2----8)-linked sialic acid units. We have used two specific probes for the detection of...

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