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异丙碘胺

异丙碘胺用途

Isopropamide iodide 是一种长效季铵盐抗胆碱能药物。Isopropamide iodide 用于治疗消化性溃疡和其他胃肠道疾病,其特点是胃酸过多和运动过度。

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异丙碘胺名称

[ CAS 号 ]:
71-81-8

[ 中文名 ]:
异丙碘胺

[ 英文名 ]:
Isopropamide iodide

[中文别名 ]:

异丙碘铵

[英文别名 ]:

Priazimide
Isopropamide Iodide
Piaccamide
Dipramid
Priamide
Dipramide
Darbid
Priamide Eupharma
Sanulcin
Isoproponum iodide

异丙碘胺生物活性

[ 描述 ]:

Isopropamide iodide 是一种长效季铵盐抗胆碱能药物。Isopropamide iodide 用于治疗消化性溃疡和其他胃肠道疾病,其特点是胃酸过多和运动过度。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. SEEHERMAN R. Isopropamide iodide: a long-acting anticholinergic. Del Med J. 1957;29(10):265‐269.

[2]. Navya sri D, et al. METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF TRIFLUOPERAZINE AND ISOPROPAMIDE IN TABLET DOSAGE FORM BY RP-HPLC. International Journal of Pharmaceutical Research & Analysis.

异丙碘胺物理化学性质

[ 密度 ]:
1.2711 (estimate)

[ 熔点 ]:
199℃ (Decomposition)

[ 分子式 ]:
C₂₃H₃₃IN₂O

[ 分子量 ]:
480.42500

[ 精确质量 ]:
480.16400

[ PSA ]:
43.09000

[ LogP ]:
1.81580

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
水溶性：实际上不溶；易溶于：氯仿,醇,甲醇；可溶于：甲醇；极微溶：乙醚,苯

异丙碘胺MSDS

详细MSDS(安全技术说明书)

异丙碘胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP0693200

CHEMICAL NAME :: Ammonium, (3-carbamoyl-3,3-diphenylpropyl)diisopropylmethyl-, iodide

CAS REGISTRY NUMBER :: 71-81-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C23-H33-N2-O.I

MOLECULAR WEIGHT :: 480.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1318,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - lacrimation Autonomic Nervous System - parasympatholytic

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,120,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - lacrimation Autonomic Nervous System - parasympatholytic

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,120,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12779 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,100,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4907 No. of Facilities: 200 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 801 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4907 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 690 (estimated) No. of Female Employees: 414 (estimated)

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异丙碘胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
BP0693200

[ 海关编码 ]:
2924299090

异丙碘胺合成路线

详细合成路线

异丙碘胺上下游产品

异丙碘胺上游产品

异丙碘胺下游产品

异丙碘胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%