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(1R,2R)-2-氨基-1-(4-硝基苯基)丙烷-1,3-二醇

用途

Chloramphenicol base is a bioactive chemical.

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名称

[ CAS 号 ]:
716-61-0

[ 中文名 ]:
(1R,2R)-2-氨基-1-(4-硝基苯基)丙烷-1,3-二醇

[ 英文名 ]:
(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

[中文别名 ]:

[英文别名 ]:

2-Amino-1-(4-nitrophenyl)-1,3-propanediol
2-amino-1-(4-nitrophenyl)propane-1,3-diol
(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol
D-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-
1-(p-nitrophenyl)-2-amino-1,3-propanediol
MFCD00078126
1,3-Propanediol, 2-amino-1- (p-nitrophenyl)-
1,3-Propanediol, 2-amino-1- (4-nitrophenyl)-
EINECS 211-938-7

物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
451.9±45.0 °C at 760 mmHg

[ 熔点 ]:
163-165ºC

[ 分子式 ]:
C₉H₁₂N₂O₄

[ 分子量 ]:
212.203

[ 闪点 ]:
227.1±28.7 °C

[ 精确质量 ]:
212.079712

[ PSA ]:
112.30000

[ LogP ]:
0.13

[ 外观性状 ]:
淡黄色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.630

[ 储存条件 ]:
−20°C

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY3100000

CHEMICAL NAME :: 1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, D-threo-(-)-

CAS REGISTRY NUMBER :: 716-61-0

LAST UPDATED :: 199406

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H12-N2-O4

MOLECULAR WEIGHT :: 212.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,207,1994

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安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
UN 3259

[ WGK德国 ]:
3

[ RTECS号 ]:
TY3100000

制备

由对硝基-α-乙酰胺基-β-羟基苯丙酮经还原、水解、中和、拆分而得。

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文献

[Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent].

Yao Xue Xue Bao 25(6) , 430-4, (1990)

Threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 was found to be a useful resolving agent for racemic gossypol. The optical and chemical stability of the condensate of enantiomeric gossyp...

Investigation of Batten disease with the yeast Saccharomyces cerevisiae.

Mol. Genet. Metab. 66(4) , 314-9, (1999)

The CLN3 gene, which encodes the protein whose absence is responsible for Batten disease, the most common inherited neurovisceral storage disease of childhood, was identified in 1995. The function of ...

High-performance liquid chromatographic determination of chloramphenicol and 2-amino-1-(p-nitrophenyl)-1,3-propanediol in pharmaceutical formulations.

J. Chromatogr. A. 170(1) , 282-7, (1979)

更多文献

(1R,2R)-2-氨基-1-(4-硝基苯基)丙烷-1,3-二醇

用途

名称

物理化学性质

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

安全信息

制备

文献

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