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R-吡咯烷-3-甲酸

R-吡咯烷-3-甲酸用途

(R) -吡咯烷-3-羧酸是脯氨酸衍生物[1]。

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R-吡咯烷-3-甲酸名称

[ CAS 号 ]:
72580-54-2

[ 中文名 ]:
(R)-吡咯烷-3-羧酸

[ 英文名 ]:
(R)-pyrrolidine-3-carboxylic acid

[中文别名 ]:

[英文别名 ]:

3-Pyrrolidinecarboxylic acid
(S)-Pyrrolidine-3-carboxylic acid
Pyrrolidine-3-carboxylic acid
UNII:XQ9918NB1D
MFCD06738463
(R)-pyrrolidine-3-carboxylic acid

R-吡咯烷-3-甲酸生物活性

[ 描述 ]:

(R) -吡咯烷-3-羧酸是脯氨酸衍生物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。

[参考文献]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

R-吡咯烷-3-甲酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
252.2±33.0 °C at 760 mmHg

[ 分子式 ]:
C₅H₉NO₂

[ 分子量 ]:
115.131

[ 闪点 ]:
106.3±25.4 °C

[ 精确质量 ]:
115.063332

[ PSA ]:
49.33000

[ LogP ]:
-0.47

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.487

[ 储存条件 ]:
2-8°C

R-吡咯烷-3-甲酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2942000000

R-吡咯烷-3-甲酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

R-吡咯烷-3-甲酸文献

Diastereocontrolled synthesis of enantioenriched 3,4-disubstituted beta-prolines.

J. Org. Chem. 72 , 398, (2007)

Enantioenriched 3,4-disubstituted beta-prolines have been prepared with a high diastereocontrol through a carbometalation reaction or through a domino Michael addition/carbometalation reaction.

Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor.

J. Med. Chem. 35 , 233, (1992)

3-Carboxy-3,4-dehydropyrrolidine was found to bind with affinity equal to that of glycine in a [3H]strychnine binding assay. Simple substitution of the 1-, 2-, 4-, or 5-position resulted in marked los...

Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance.

J. Med. Chem. 45(12) , 2571-8, (2002)

In this paper we describe the synthesis and affinity toward the mu-opioid receptor of some tetrapeptides obtained from endomorphin-1, H-Tyr-Pro-Trp-Phe-NH(2) (1), by substituting each amino acid in tu...

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