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氘代吡啶-d5

氘代吡啶-d5用途

吡啶-d5是氘标记的吡啶[1]。

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氘代吡啶-d5名称

[ CAS 号 ]:
7291-22-7

[ 中文名 ]:
吡啶-d5

[ 英文名 ]:
Pyridine-d5

[中文别名 ]:

[英文别名 ]:

EINECS 230-720-2
4-Methyl-benzenamine-d7
[D5]pyridine
Perdeutero-p-toluidin
4-Aminotoluene-d7
Pyridine-d
(H)Pyridine
4-Toluidine-d7 (Major)
4-Methyl-1-aminobenzene-d7
4-Methylphenylamine-d7

氘代吡啶-d5生物活性

[ 描述 ]:

吡啶-d5是氘标记的吡啶[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

氘代吡啶-d5物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
115.3±0.0 °C at 760 mmHg

[ 熔点 ]:
-41ºC

[ 分子式 ]:
C₅D₅N

[ 分子量 ]:
84.131

[ 闪点 ]:
20.0±0.0 °C

[ 精确质量 ]:
84.073586

[ PSA ]:
12.89000

[ LogP ]:
0.73

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
22.8±0.2 mmHg at 25°C

[ 折射率 ]:
1.501

[ 储存条件 ]:
2-8°C

氘代吡啶-d5MSDS

氘代吡啶-d5安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Highlyflammable;Xn:Harmful;

[ 风险声明 (欧洲) ]:
R11;R20/21/22

[ 安全声明 (欧洲) ]:
S26-S28

[ 危险品运输编码 ]:
UN1282

[ WGK德国 ]:
3

[ 包装等级 ]:
II

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氘代吡啶-d5文献

25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.

J. Ethnopharmacol. 164 , 265-72, (2015)

Quisqualis indica is used in traditional Chinese medicine to treat cancer and related syndromes and also known for its anthelminthic effects.Soft tissue sarcomas represent a rare group of malignant tu...

Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis.

Fitoterapia 99 , 191-7, (2014)

Six new 9,19-cycloartane triterpenes (1-6) were isolated from the aerial parts of Cimicifuga yunnanensis. The new chemical structures were determined by extensive analyses of 1D and 2D NMR spectroscop...

Triterpenoids from the Herbs of Salicornia bigelovii.

Molecules 20 , 20334-40, (2015)

A new nortriterpene saponin, 3-O-β-d-glucuronopyranosyl-30-norolean-12,20(29)-dien-23- oxo-28-oic acid, namely bigelovii D (11), was isolated from the hydroalcoholic extract of herbs of Salicornia big...

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