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甘油-d8

甘油-d8用途

甘油-d8是氘标记的甘油[1]。

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甘油-d8名称

[ CAS 号 ]:
7325-17-9

[ 中文名 ]:
丙三醇-d8

[ 英文名 ]:
Glycerol-d8

[英文别名 ]:

MFCD00084149
1,2,3-Propanetriol-d8
Glycerol-d8
Glycerin-d8
Deuterated glycerol

甘油-d8生物活性

[ 描述 ]:

甘油-d8是氘标记的甘油[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

甘油-d8物理化学性质

[ 密度 ]:
1.371 g/mL at 25ºC

[ 沸点 ]:
182ºC(lit.)

[ 熔点 ]:
20ºC(lit.)

[ 分子式 ]:
C₃D₈O₃

[ 分子量 ]:
100.14300

[ 闪点 ]:
>230 °F(lit.)

[ 精确质量 ]:
100.09800

[ PSA ]:
60.69000

[ 折射率 ]:
n20/D 1.466(lit.)

[ 储存条件 ]:
室温，密封，干燥

甘油-d8MSDS

详细MSDS(安全技术说明书)

甘油-d8安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

甘油-d8文献

Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.

Eur. J. Pharm. Sci. 77 , 180-8, (2015)

In mammalian brain, monoacylglycerol lipase (MAGL) is the primary enzyme responsible for terminating signaling function of the endocannabinoid 2-arachidonoylglycerol (2-AG). Previous in vivo studies w...

Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins.

J. Am. Chem. Soc. 137 , 9302-14, (2015)

Using the single-chain due ferri (DFsc) peptide scaffold, the differential oxidase and oxygenase reactivities of two 4A→4G variants, one with two histidines at the diiron center (G4DFsc) and the other...

Distribution of bioactive lipid mediators in human skin.

J. Invest. Dermatol. 135 , 1510-20, (2015)

The skin produces bioactive lipids that participate in physiological and pathological states, including homeostasis, induction, propagation, and resolution of inflammation. However, comprehension of t...

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