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Α-甲基-DL-酪氨酸甲酯盐酸盐

Α-甲基-DL-酪氨酸甲酯盐酸盐用途

α-甲基酪氨酸甲酯盐酸盐是一种竞争性酪氨酸羟化酶抑制剂,抑制酪氨酸向多巴胺的转化。α-甲基酪氨酸甲酯盐酸盐可用作交感神经系统研究的工具[1]。

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Α-甲基-DL-酪氨酸甲酯盐酸盐名称

[ CAS 号 ]:
7361-31-1

[ 中文名 ]:
Alpha-甲基-DL-酪氨酸甲酯盐酸盐

[ 英文名 ]:
alpha-methyl-dl-tyrosine methyl ester hydrochloride

[中文别名 ]:

Α-甲基-DL-酪氨酸甲酯盐酸盐

[英文别名 ]:

MFCD00012606
EINECS 230-900-0
AMPT

Α-甲基-DL-酪氨酸甲酯盐酸盐生物活性

[ 描述 ]:

α-甲基酪氨酸甲酯盐酸盐是一种竞争性酪氨酸羟化酶抑制剂,抑制酪氨酸向多巴胺的转化。α-甲基酪氨酸甲酯盐酸盐可用作交感神经系统研究的工具[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. G Magnusson, et al. Renal lesions induced by alpha-methyltyrosine methylester and alpha-methyltyrosine. Acta Pharmacol Toxicol (Copenh). 1970;28(6):435-44.

Α-甲基-DL-酪氨酸甲酯盐酸盐物理化学性质

[ 沸点 ]:
336.4ºC at 760 mmHg

[ 熔点 ]:
192 °C (dec.)(lit.)

[ 分子式 ]:
C₁₁H₁₆ClNO₃

[ 分子量 ]:
245.70300

[ 闪点 ]:
157.2ºC

[ 精确质量 ]:
245.08200

[ PSA ]:
72.55000

[ LogP ]:
2.32740

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, faintly yellow

Α-甲基-DL-酪氨酸甲酯盐酸盐MSDS

详细MSDS(安全技术说明书)

Α-甲基-DL-酪氨酸甲酯盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2900000

CHEMICAL NAME :: p-Tyrosine, alpha-methyl-, methyl ester, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 7361-31-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H15-N-O3.Cl-H

MOLECULAR WEIGHT :: 245.73

WISWESSER LINE NOTATION :: QR D1XZ1&VO1 &GH, -R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,227,1974

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Α-甲基-DL-酪氨酸甲酯盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YP2900000

[ 海关编码 ]:
2922509090

Α-甲基-DL-酪氨酸甲酯盐酸盐海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Α-甲基-DL-酪氨酸甲酯盐酸盐文献

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

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Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.

Br. J. Pharmacol. 141(1) , 132-40, (2004)

1. The ORL1 agonists nociceptin and Ro 64-6198 were compared in their ability to modify spontaneous locomotor activity in male NMRI mice not habituated to the test environment. 2. Higher doses of noci...

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