< 生产厂家价格 >

Leukotriene D4

Leukotriene D4用途

白三烯D4是γ-谷氨酰转肽酶代谢LTC4产生的过敏反应慢反应物质(SRS-A)的成分之一。白三烯D4是LTC4的第一个半胱氨酸白三烯代谢物。白三烯D4诱导的支气管收缩和血管通透性增强是哮喘和急性超敏反应的发病机制之一。

点击显示

Leukotriene D4名称

[ CAS 号 ]:
73836-78-9

[ 中文名 ]:
白三烯D4

[ 英文名 ]:
Leukotriene D4

[英文别名 ]:

Leukotriene D4
LTD4
leukotriened

Leukotriene D4生物活性

[ 描述 ]:

Leukotriene D4物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
748.3±70.0 °C at 760 mmHg

[ 分子式 ]:
C₂₅H₄₀N₂O₆S

[ 分子量 ]:
496.660

[ 闪点 ]:
406.4±35.7 °C

[ 精确质量 ]:
496.260712

[ PSA ]:
175.25000

[ LogP ]:
5.78

[ 蒸汽压 ]:
0.0±5.7 mmHg at 25°C

[ 折射率 ]:
1.538

[ 储存条件 ]:
-20°C，密闭，干燥

Leukotriene D4毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9143000

CHEMICAL NAME :: Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecat etraenyl)-L-cysteinyl )-, (R- (R*,S*-(E,E,Z,Z)))-

CAS REGISTRY NUMBER :: 73836-78-9

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H40-N2-O6-S

MOLECULAR WEIGHT :: 496.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 10 nmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 51,5573,1991

点击显示

Leukotriene D4安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F: Flammable;T: Toxic;

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
UN 1230 3/PG 2

Leukotriene D4文献

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.

Nat. Neurosci. 18(1) , 145-53, (2015)

The primary sensory system requires the integrated function of multiple cell types, although its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 single mouse neuro...

Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.

J. Immunol. 191(12) , 5807-10, (2013)

Leukotriene C4 (LTC4) and its extracellular metabolites, LTD4 and LTE4, mediate airway inflammation. They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99)...

A contraction assay system using primary cultured mouse bronchial smooth muscle cells.

Int. Arch. Allergy Immunol. 161 Suppl 2 , 93-7, (2013)

Contraction of bronchial smooth muscle is the main mechanism of asthmatic responses. Inflammatory cells such as eosinophils and mast cells produce chemical mediators that induce smooth muscle contract...

更多文献