甲硫醇

DATA ITEMS CITED :

36

MOLECULAR FORMULA :

C-H4-S

MOLECULAR WEIGHT :

48.11

WISWESSER LINE NOTATION :

SH1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

675 ppm

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6530 ug/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

60670 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

17 ppm/7H/13W-I

TOXIC EFFECTS :

Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

MUTATION DATA

TEST SYSTEM :

Insect - Drosophila melanogaster

REFERENCE :

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 7,286,1974 *** REVIEWS *** ACGIH TLV-TWA 0.98 mg/m3 (0.5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 ppm (1 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,167,1971 OSHA PEL (Gen Indu):CL 10 ppm (20 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 10 ppm (20 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 ppm (1 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.5 ppm (0.98 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.5 ppm (1 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.5 ppm (1 mg/m3);STEL 1.5 ppm (3 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.5 ppm (1 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.5 ppm (1 mg/m3) JAN 1993 OEL-HUNGARY:STEL 1 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 ppm (1 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 10 ppm (20 mg/m3) JAN 1993 OEL-RUSSIA:STEL 0.8 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.5 ppm (1 mg/m3);STEL 1 ppm (2 mg/m3) JAN 1993 OEL-THAILAND:TWA 10 ppm (20 mg/m3) JAN 1993 OEL-TURKEY:TWA 10 ppm (20 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 ppm (1 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHANETHIOL-air:CL 0.5 ppm/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 45850 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 357 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 45850 No. of Facilities: 147 (estimated) No. of Industries: 7 No. of Occupations: 25 No. of Employees: 6192 (estimated) No. of Female Employees: 380 (estimated)