< 生产厂家价格 >

PGF1α(前列腺素F1α)

PGF1α(前列腺素F1α)名称

[ CAS 号 ]:
745-62-0

[ 中文名 ]:
前列腺素F1Alpha

[ 英文名 ]:
Prostaglandin F1α

[中文别名 ]:

前列腺素F1α

[英文别名 ]:

protaglandinf1
prostaglandin F1alpha
PGF1ALPHA
PGF1
EINECS 234-237-8
PROSTAGLANDIN F1A
Prostaglandin F1α
prostaglandinf1
PROSTAGLANDINS F1ALPHA
syntheticwhitecrystallinesolid

PGF1α(前列腺素F1α)物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
526.5±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₆O₅

[ 分子量 ]:
356.497

[ 闪点 ]:
286.3±26.6 °C

[ 精确质量 ]:
356.256287

[ PSA ]:
97.99000

[ LogP ]:
2.60

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
-20°C

PGF1α(前列腺素F1α)MSDS

详细MSDS(安全技术说明书)

PGF1α(前列腺素F1α)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY4569700

CHEMICAL NAME :: Cyclopentaneheptanoic acid, 3,5-dihydroxy-2-(3-hydroxy-1-octenyl)-

CAS REGISTRY NUMBER :: 745-62-0

LAST UPDATED :: 198910

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H36-O5

MOLECULAR WEIGHT :: 356.56

WISWESSER LINE NOTATION :: L5TJ AQ B6VQ C1U1YQ5 DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 150 mg/kg

SEX/DURATION :: female 4-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 45 mg/kg

SEX/DURATION :: male 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 3 mg/kg

REFERENCE :: INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,82,1976

点击显示

PGF1α(前列腺素F1α)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
GY4569700

PGF1α(前列腺素F1α)文献

Influence of human low density and high density lipoprotein cholesterol on the in vitro prostaglandin I2 synthetase activity.

Biochim. Biophys. Acta 620(3) , 352-5, (1980)

We investigated in vitro the influence of low density lipoprotein (LDL) cholesterol and high density lioprotein (HDL) cholesterol separated from human serum on prostaglandin I2 synthetase activity stu...

Native pentameric C-reactive protein displays more potent pro-atherogenic activities in human aortic endothelial cells than modified C-reactive protein.

Atherosclerosis 184(1) , 48-52, (2006)

Inflammation is pivotal in atherogenesis. Numerous prospective studies have shown that levels of high sensitive C-reactive protein (CRP) predict cardiovascular events. Recently, data suggests that CRP...

Long-term fenofibrate treatment impairs endothelium-dependent dilation to acetylcholine by altering the cyclooxygenase pathway.

Cardiovasc. Res. 75(2) , 398-407, (2007)

Experimental studies and opinion articles emphasize that cardiovascular alterations associated with ageing can be improved by the long-term use of fenofibrates. We analyzed the effect of fenofibrate t...

更多文献