螺铂
螺铂用途
Spiroplatin(TNO-6)是一种新型含铂类似物,具有抗肿瘤活性,常用用于研究实体肿瘤。
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螺铂名称
螺铂生物活性
[ 描述 ]:
Spiroplatin(TNO-6)是一种新型含铂类似物,具有抗肿瘤活性,常用用于研究实体肿瘤。
[参考文献]
1. Schroyens W, et al. Comparative effect of cisplatin, spiroplatin, carboplatin and iproplatin in a human tumor clonogenic assay. J Cancer Res Clin Oncol. 1990;116(4):392-6.
螺铂物理化学性质
[ 沸点 ]:
198.8ºC at 760 mmHg
[ 分子式 ]:
C8H18N2O4PtS
[ 分子量 ]:
433.38300
[ 闪点 ]:
83.9ºC
[ 精确质量 ]:
433.06400
[ PSA ]:
140.68000
[ LogP ]:
1.99520
螺铂毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TP2283000
- CHEMICAL NAME :
- Platinum, (1,1-cyclohexanedimethanamine-N,N')(sulfato(2-)-O,O') -, (SP-4-2)-
- CAS REGISTRY NUMBER :
- 74790-08-2
- LAST UPDATED :
- 199601
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C8-H18-N2-O4-Pt-S
- MOLECULAR WEIGHT :
- 433.43
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3 mg/kg/9W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - proteinuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Kidney
- DOSE/DURATION :
- 1500 nmol/L
- REFERENCE :
- EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 25,27,1989
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