二氯甲烷_MSDS_用途_密度_二氯甲烷CAS号【75-09-2】

【用途一】
用作溶剂，也用于有机合成
【用途二】
是不燃性低沸点溶剂，作醋酸纤维素成膜、气溶胶和抗菌素、维生素生产中的溶剂，也用作萃取剂、金属清洗剂等
【用途三】
二氯甲烷是杀菌剂腈菌唑和咪菌唑生产的原料，也是一种很好的溶剂。
【用途四】
萃取溶剂。如用于萃取咖啡豆中的咖啡因。并用作酒花、香辛料油树脂等抽提溶剂。色素稀释剂。
【用途五】
该品除用于有机合成外，还广泛用作醋酸纤维素成膜，三醋酸纤维素抽丝，石油脱蜡，气溶胶和抗生素、维生素、甾族化合物生产中的溶剂，以及金属表面漆层清洗脱脂及脱膜剂。此外，还用于谷物熏蒸和低压冷冻机及空调装置的制冷。在聚醚型尿烷泡沫塑料生产中用作辅助发泡剂，以及用作挤压聚砜型泡沫塑料的发泡剂。

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[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
39.6±0.0 °C at 760 mmHg

[ 熔点 ]:
-97 °C

[ 分子式 ]:
CH₂Cl₂

[ 分子量 ]:
84.933

[ 闪点 ]:
-14.1±22.4 °C

[ 精确质量 ]:
83.953354

[ LogP ]:
1.19

[ 外观性状 ]:
一种无色液体带有一种甜的,渗透的,像醚的气味

[ 蒸汽密度 ]:
2.9 (vs air)

[ 蒸汽压 ]:
448.0±0.0 mmHg at 25°C

[ 折射率 ]:
1.398

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、硝酸分开存放

[ 水溶解性 ]:
20 g/L (20 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA8050000

CHEMICAL NAME :: Methane, dichloro-

CAS REGISTRY NUMBER :: 75-09-2

BEILSTEIN REFERENCE NO. :: 1730800

LAST UPDATED :: 199712

DATA ITEMS CITED :: 119

MOLECULAR FORMULA :: C-H2-Cl2

MOLECULAR WEIGHT :: 84.93

WISWESSER LINE NOTATION :: G1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 357 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - paresthesis Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 500 ppm/1Y-I

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Cardiac - change in rate

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 500 ppm/8H

TOXIC EFFECTS :: Behavioral - euphoria

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 916 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14400 ppm/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 437 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4770 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 14108 ppm/7H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Liver - liver function tests impaired

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 43400 mg/m3/4.5H

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10000 ppm/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5000 ppm/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 91 gm/kg/2Y-C

TOXIC EFFECTS :: Behavioral - fluid intake Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 ppm/5H/4W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5000 ppm/24H/14W-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 ppm/6H/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44 mg/m3/24H/96D-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 39270 mg/kg/17W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1862 mg/kg/2W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13000 ppm/6H/19D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 ppm/24H/30D-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5000 ppm/24H/7D-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ppm/24H/90D-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1000 ppm/24H/7W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Musculoskeletal - other changes Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 5000 ppm/24H/32D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 552 ppm/6H/5D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2000 ppm/5H/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 4500 ppm/24H

SEX/DURATION :: female 1-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1250 ppm/7H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1250 ppm/7H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 367,143,1996 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 174 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,43,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,43,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,194,1987 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 500 ppm (1750 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,171,1971 OSHA PEL (Gen Indu):8H TWA 500 ppm;CL 1000 ppm;Pk 2000 ppm/5M/2H CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):see 56 FR 57036 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 500 ppm (1740 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 500 ppm (1740 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 100 ppm (350 mg/m3);Carcinogen JAN 1993 OEL-AUSTRIA:TWA 100 ppm (360 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (174 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 50 ppm (175 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 100 ppm (350 mg/m3);STEL 250 ppm (870 mg/m3) JAN 1993 OEL-FRANCE:TWA 100 ppm (360 mg/m3);STEL 500 ppm (1800 mg/m3) JAN 1993 OEL-GERMANY:TWA 100 ppm (360 mg/m3);Carcinogen JAN 1993 OEL-HUNGARY:STEL 10 mg/m3;Carcinogen JAN 1993 OEL-JAPAN:TWA 100 ppm (350 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 100 ppm (350 mg/m3);STEL 500 ppm JAN 1993 OEL-THE PHILIPINES:TWA 500 ppm (1740 mg/m3) JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:TWA 100 ppm;STEL 50 mg/m3 JAN 1993 OEL-SWEDEN:TWA 35 ppm (120 mg/m3);STEL 70 ppm (250 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 100 ppm (360 mg/m3);STEL 500 ppm JAN 1993 OEL-THAILAND:TWA 500 mg/m3;STEL 1000 mg/m3 JAN 1993 OEL-TURKEY:TWA 500 ppm (1740 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (350 mg/m3);STEL 250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYLENE CHLORIDE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 47270 No. of Facilities: 89025 (estimated) No. of Industries: 374 No. of Occupations: 192 No. of Employees: 975696 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 47270 No. of Facilities: 87086 (estimated) No. of Industries: 363 No. of Occupations: 212 No. of Employees: 1438196 (estimated) No. of Female Employees: 352536 (estimated)

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[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H336-H351-H373

[ 警示性声明 ]:
P261-P281-P305 + P351 + P338

[ 靶器官 ]:
Blood, Central nervous system, Liver

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S23-S24/25-S36/37-S45-S16-S7

[ 危险品运输编码 ]:
UN 1593 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
PA8050000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2903120001

详细合成路线

二氯甲烷上游产品

二氯甲烷下游产品

1.甲烷氯化法：将甲烷、氯气与循环气混合后，送入反应器，于380～400℃进行热氯化反应。气体反应产物经冷却器冷却至70～80℃后，送入氯化氢吸收塔，用水吸收除去气体产物中的氯化氢，再送入碱洗塔，用碱液中和除去残留的盐酸和游离氯。经过净化后的气体产物经压缩、冷却、冷凝为粗氯化物。粗氯化物送入蒸馏工序，经各个蒸馏塔分别蒸出氯甲烷，二氯甲烷和三氯甲烷，不凝气除一部分放空外，其余与新料混合循环使用。控制操作条件为反应温度400～420℃，配料比CH4∶Cl2=4∶1，可得以二氯甲烷为主的产品。

2.甲醇氨化法：甲醇在气化器中气化后，同后续反应分离出的氯化氢混合，经催化剂氧化铝或以活性炭或浮石为载体的氯化亚酮或氯化锌，也可用载于活性炭上的磷酸为催化剂，在加氢氯化器中于350℃进行反应，生成氯甲烷。气态反应产物在水洗塔或碱洗塔中分别用冷水和氢氧化钠溶液洗涤，除去未反应的甲醇和氯化氢后，送入脱氢塔，用硫酸再次洗涤除去反应过程中生成的二甲醚和水，得到氯甲烷。氯甲烷与氯气在410～420℃反应，生成二氯甲烷和三氯甲烷，同时还生成少量四氯化碳。经骤冷，分成含二氯乙烷的液相和含未冷凝的氯化氢，未反应的氯甲烷，氯气的气相。气相分离出氯化氢、氯甲烷和氯气分别循环使用。液相先送入吸收塔用稀碱和水洗涤，除去四氯化碳，再送入精馏塔通过共沸蒸馏和精馏，分别获得二氯甲烷和三氯甲烷。

3.氯甲烷氯化氯甲烷氯化分光氯化和热氯化两种工艺。
光氯化是将氯甲烷与氯气在4000kW光照下进行反应，反应产物经碱洗、压缩、冷凝、干燥、精馏而得成品。
热氯化是将氯甲烷与氯气按(2～2.5)∶1(质量)配料，于反应温度为400℃，反应压力为0.2MPa下进行反应。反应产物经水洗、碱洗、压缩、冷凝、干燥、精馏而得成品。

4.以工业品二氯甲烷为原料，用原料体积的1／8～1／10的浓硫酸洗涤数次至酸层无色，再用5%的氢氧化钠溶液洗涤一次，用量为原料体积的1／5，用水洗涤二次。然后用无水氯化钙干燥，吸出清液后蒸馏，收集中间馏分，即得二氯甲烷纯品。

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Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route.

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Polycaprolactone (PCL) matrices were simultaneously loaded with the antiviral agents, tenofovir (TFV) and nevirapine (NVP), in combination to provide synergistic activity in the prevention of HIV tran...

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Novel PEGylated PLA nanocapsules (PEG-AcPLA nanocapsules), loading high percentage of water soluble drugs have been formulated by using multiple emulsion technique without using conventional stabilize...

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：二氯甲烷

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥568.0/4l ￥需询单/1mg ￥68.0/500ml ￥118.0/100ml

联系人：刘佳

产品详情：二氯甲烷

公司名：中山市迪欣化工有限公司

区域：中山市三角镇

价格：
￥15.0/250kg

联系人：陈雪萍

产品详情：二氯甲烷

公司名：山东金悦源新材料有限公司

区域：济南市天桥区

价格：
￥500.0/250kg ￥2000.0/1ton

联系人：王思兵

产品详情：二氯甲烷

公司名：济南世纪通达化工有限公司

区域：济南市天桥区

价格：
￥3500.0/1ton ￥7000.0/2ton

联系人：王经理

产品详情：二氯甲烷

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二氯甲烷是极性分子还是非极性分子？

2019-07-18 17:43:19

二氯甲烷，CH2Cl2是极性分子，没有同分异构体，因为C周围的4个原子呈四面体分布，是空间的。CH2Cl2是四面体，不是正四面体，因为C-H与C-Cl距离不等CH4，CCl4是正四面体。因为是四面体结构，没有对称中心DCE非极性，以能量最稳定的全交叉构象看，有一个对称中心，偶极距=0，跟C-H，C...

二氯甲烷

二氯甲烷用途

二氯甲烷名称

二氯甲烷物理化学性质