磷酸二氢钠

磷酸二氢钠用途

磷酸二氢钠(NaH2PO4,NDHP)是钠与磷酸盐抗衡离子的化合物。山梨醇单油酸酯与其他磷酸钠结合,可以作为pH缓冲液。磷酸二氢钠可用作辅料,如缓冲剂、螯合剂等。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

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磷酸二氢钠名称

[ CAS 号 ]:
7558-80-7

[ 中文名 ]:
无水磷酸二氢钠

[ 英文名 ]:
sodium dihydrogenphosphate

[中文别名 ]:

磷酸二氢钠

[英文别名 ]:

Sodium dihydrogen (16O4)phosphate
Sodium dihydngen phoshate anhydrous
MFCD04113752
EINECS 231-449-2

磷酸二氢钠生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kumar H, et al. Investigations on solute–solvent interactions of amino acids in aqueous solutions of sodium dihydrogen phosphate at different temperatures[J]. Monatshefte für Chemie-Chemical Monthly, 2014, 145: 1063-1082.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

磷酸二氢钠物理化学性质

[ 密度 ]:
1.40 g/mL at 20 °C

[ 沸点 ]:
100°C

[ 熔点 ]:
<0ºC

[ 分子式 ]:
H₂NaO₄P

[ 分子量 ]:
119.98

[ 精确质量 ]:
119.958839

[ PSA ]:
90.40000

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with heavy metals, strong acids.

[ 水溶解性 ]:
H2O: 5 M, clear, colorless

磷酸二氢钠MSDS

详细MSDS(安全技术说明书)

磷酸二氢钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WA1900000

CAS REGISTRY NUMBER :: 7558-80-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: H2-O4-P.Na

MOLECULAR WEIGHT :: 119.98

WISWESSER LINE NOTATION :: NA P-O2-Q2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,349,1959

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,349,1959 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,16,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29, 1943-71. Suspended. Volume(issue)/page/year: 4,223,1946 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83818 No. of Facilities: 9820 (estimated) No. of Industries: 107 No. of Occupations: 77 No. of Employees: 49018 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83818 No. of Facilities: 13232 (estimated) No. of Industries: 123 No. of Occupations: 104 No. of Employees: 289281 (estimated) No. of Female Employees: 145939 (estimated)

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磷酸二氢钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
WA1900000

[ 海关编码 ]:
2835220000

磷酸二氢钠制备

工业生产方法有磷酸氢二钠中和法和纯碱中和法。
1磷酸氢二钠中和法将十二水磷酸氢二钠按3∶2的配比加水溶解，经过滤除去不溶物，把滤液加入中和器，在搅拌下缓慢加入磷酸进行中和反应，控制pH值在4.2～4.6，反应溶液经蒸发浓缩至形成结晶膜为止，经冷却结晶，离心分离，得二水磷酸二氢钠。然后在100℃干燥，制得无水磷酸二氢钠成品。其反应式如下：

母液可返回作溶解磷酸氢二钠用。
2纯碱中和法将萃取磷酸加入中和反应器中，在搅拌下缓慢加入纯碱溶液进行中和反应，生成磷酸二氢钠，经过滤，蒸发浓缩，冷却至60～70℃析出结晶，离心分离，得二水磷酸二氢钠。再经气流干燥，制得无水磷酸二氢钠成品。其反应式如下：

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磷酸二氢钠海关

[ 海关编码 ]: 2835220000

磷酸二氢钠文献

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磷酸二氢钠

磷酸二氢钠用途

磷酸二氢钠名称

磷酸二氢钠生物活性

磷酸二氢钠物理化学性质

磷酸二氢钠MSDS

详细MSDS(安全技术说明书)

磷酸二氢钠毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

磷酸二氢钠安全信息

磷酸二氢钠制备

磷酸二氢钠海关

磷酸二氢钠文献

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