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5-羟基-2-甲基吲哚-3-羧酸乙酯

5-羟基-2-甲基吲哚-3-羧酸乙酯用途

5-羟基-2-甲基-1H-吲哚-3-羧酸乙酯是一种活性化合物,可用于合成2-苯基硫甲基吲哚衍生物,2-苯基硫基甲基吲哚衍生物是5-脂氧合酶(5-LO)抑制剂[1]。

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5-羟基-2-甲基吲哚-3-羧酸乙酯名称

[ CAS 号 ]:
7598-91-6

[ 中文名 ]:
5-羟基-2-甲基吲哚-3-羧酸乙酯

[ 英文名 ]:
Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate

[中文别名 ]:

[英文别名 ]:

MFCD00044575
ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate
EINECS 231-507-7

5-羟基-2-甲基吲哚-3-羧酸乙酯生物活性

[ 描述 ]:

5-羟基-2-甲基-1H-吲哚-3-羧酸乙酯是一种活性化合物,可用于合成2-苯基硫甲基吲哚衍生物,2-苯基硫基甲基吲哚衍生物是5-脂氧合酶(5-LO)抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

5-羟基-2-甲基吲哚-3-羧酸乙酯物理化学性质

[ 密度 ]:
1.282 g/cm3

[ 沸点 ]:
406.7ºC at 760 mmHg

[ 熔点 ]:
205-208ºC(lit.)

[ 分子式 ]:
C₁₂H₁₃NO₃

[ 分子量 ]:
219.23700

[ 闪点 ]:
199.7ºC

[ 精确质量 ]:
219.09000

[ PSA ]:
62.32000

[ LogP ]:
2.35860

[ 外观性状 ]:
灰白色至淡黄褐色的结晶粉末

[ 折射率 ]:
1.5270 (estimate)

[ 储存条件 ]:
室温，干燥

5-羟基-2-甲基吲哚-3-羧酸乙酯MSDS

5-羟基-2-甲基吲哚-3-羧酸乙酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F+

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

[ 海关编码 ]:
2933990090

5-羟基-2-甲基吲哚-3-羧酸乙酯合成路线

5-羟基-2-甲基吲哚-3-羧酸乙酯上下游产品

5-羟基-2-甲基吲哚-3-羧酸乙酯上游产品

5-羟基-2-甲基吲哚-3-羧酸乙酯下游产品

5-羟基-2-甲基吲哚-3-羧酸乙酯海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-羟基-2-甲基吲哚-3-羧酸乙酯文献

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

J. Med. Chem. 51 , 4351, (2008)

1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 5...

Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.

J. Med. Chem. 45 , 3094, (2002)

Previously, we reported on PD 102807 (41) as being the most selective synthetic M(4) muscarinic antagonist identified to date. Synthesized analogues of 41 showed no improvement in affinity and selecti...

5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

J. Med. Chem. 52 , 3855, (2009)

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different spec...

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