4-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy]aniline dihydrochlorid e

名称

[ CAS 号 ]:
76487-32-6

[ 英文名 ]:
4-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy]aniline dihydrochlorid e

物理化学性质

[ 沸点 ]:
538.3ºC at 760 mmHg

[ 分子式 ]:
C₂₀H₂₉Cl₂N₃O₂

[ 分子量 ]:
414.36900

[ 闪点 ]:
279.3ºC

[ 精确质量 ]:
413.16400

[ PSA ]:
50.96000

[ LogP ]:
5.05660

[ 储存条件 ]:
库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK8065000

CHEMICAL NAME :: Piperazine, 1-(3-(p-aminophenoxy)propyl)-4-(o-methoxyphenyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 76487-32-6

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H27-N3-O2.2Cl-H

MOLECULAR WEIGHT :: 414.42

WISWESSER LINE NOTATION :: T6N DNTJ A3OR DZ& DR BO1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 416 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 6,346,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 319 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 6,346,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 6,346,1981

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