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胺菊酯

胺菊酯用途

Tetramethrin 是一种合成的拟除虫菊酯类杀虫剂,可用于多种害虫。
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胺菊酯名称

[ CAS 号 ]:
7696-12-0

[ 中文名 ]:
胺菊酯

[ 英文名 ]:
Tetramethrin

[中文别名 ]:

[英文别名 ]:

胺菊酯生物活性

[ 描述 ]:

Tetramethrin 是一种合成的拟除虫菊酯类杀虫剂,可用于多种害虫。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[体内研究]

毒鼠强作用于昆虫的神经系统,通过与钠通道的相互作用干扰神经元的功能[1]。

[参考文献]

[1]. Pengfei Zhao,et al. Stereoselective Analysis of Chiral Pyrethroid Insecticides Tetramethrin and α-Cypermethrin in Fruits, Vegetables, and Cereals. J Agric Food Chem. 2019 Aug 21;67(33):9362-9370.

胺菊酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
453.2±45.0 °C at 760 mmHg

[ 熔点 ]:
60-80°C

[ 分子式 ]:
C19H25NO4

[ 分子量 ]:
331.406

[ 闪点 ]:
227.9±28.7 °C

[ 精确质量 ]:
331.178345

[ PSA ]:
63.68000

[ LogP ]:
4.78

[ 外观性状 ]:
白色晶体或粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

胺菊酯MSDS

详细MSDS(安全技术说明书)

胺菊酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GZ1730000
CHEMICAL NAME :
Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, (1,3,4,5,6,7-hexahydro- 1,3-dioxo-2H-isoindol-2-yl)methyl ester
CAS REGISTRY NUMBER :
7696-12-0
LAST UPDATED :
199612
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C19-H25-N-O4
MOLECULAR WEIGHT :
331.45
WISWESSER LINE NOTATION :
T56 BVNV&TJ C1OV- AL3TJ B1 B1 C1UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2500 mg/m3/3H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - excitement Kidney, Ureter, Bladder - urine volume increased
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
548 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
527 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1950 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
50 mg/L
REFERENCE :
ZYDXDM Zhejiang Yike Daxue Xuebao. Journal of Zhejiang Medical University. (Zhejiang Yike Daxue, Yan'an Lu, Hanzhou, Zhejiang, Peop. Rep. China) V.1- 1972(?)- Volume(issue)/page/year: 14,1,1985 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2712 No. of Facilities: 633 (estimated) No. of Industries: 10 No. of Occupations: 13 No. of Employees: 9244 (estimated) No. of Female Employees: 1759 (estimated)
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胺菊酯安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 2588

[ RTECS号 ]:
GZ1730000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2925190024

胺菊酯制备

胺醇的合成 将1，2，4，6-四氢化邻苯二甲酸杆和五氧化二磷混合在反应器中，反应温度200℃，反应结束减压蒸馏得3,4,5,6-四氢化邻苯二甲酸酐。然后将其与尿素反应，得3，4，5，6-四氢化邻苯二甲酰亚胺。将亚胺、37%甲醛溶液、1%氢氧化钠溶液混合，以二氯乙烷为溶剂，加热回流，冷却后分出有机层，水层用二氯乙烷萃取，萃取液登工有机层，并用水洗涤，减压蒸馏得粗胺醇。粗胺醇加甲苯溶解，冷却至室温使之结晶，过滤、干燥得结晶状胺醇。
菊酰氯的制备 将菊酸乙酯、液碱、乙醇在加热条件下回流皂化，pH>9，常压蒸出乙醇，加适量水，使菊酸钠溶解，再滴加10%盐酸，边搅拌加酸化，至水层pH≤2，分出有机层，水层用甲苯萃取，合并有机层，再水洗一次，蒸出甲苯得粗菊酸。将菊酸、三氯化磷和甲苯于50℃反应4h，分出亚磷酸，有机层减压脱溶，得粗菊酰氯。进一步减压蒸馏，收集96～98℃/2kPa馏分，得精菊酰氯。
胺菊酯的合成 加入胺醇、吡啶和甲苯，开动搅拌，微微加热，使胺醇全部溶解，冷却后，滴加菊酰氯甲苯溶液，滴毕于50～60℃反应2h。反应毕过滤，甲苯洗涤滤饼，合并滤液和洗涤液，用酸洗、碱洗、水洗至中性，减压脱溶，得胺菊酯原油，含量92%～93℃，收率92%以上。
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胺菊酯海关

[ 海关编码 ]: 2925190024

胺菊酯文献

Characterisation of gene expression patterns in 22RV1 cells for determination of environmental androgenic/antiandrogenic compounds.

J. Steroid Biochem. Mol. Biol. 84(2-3) , 231-8, (2003)

Alteration of androgen receptor function due to hormonally active compounds in the environment, may be responsible for impaired reproductive function in aquatic wildlife. Based on human prostate carci...

Indoor thermal fogging application of pesguard FG 161, a mixture of d-tetramethrin and cyphenothrin, using portable sprayer against vector mosquitoes in the tropical environment.

J. Am. Mosq. Control Assoc. 17(1) , 28-32, (2001)

Indoor bioefficacy of the thermal fogging application of Pesguard FG 161, a formulation containing both knockdown and killing agents (active ingredient [AI]: d-tetramethrin 4% [w/w] and cyphenothrin 1...

Differential pharmacology of the cardiac anionic background current I(AB).

Eur. J. Pharmacol. 569(3) , 163-70, (2007)

A novel anionic background conductance (I(AB)) in cardiac ventricular myocytes has recently been identified but at present there is comparatively little information on its pharmacological modulation. ...


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相关化合物

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