阿那昔酮

阿那昔酮名称

[ CAS 号 ]:
77658-97-0

[ 中文名 ]:
阿那昔酮

[ 英文名 ]:
1,2,4-Triazolidine-3,5-dione,1,2,4-tris(2-oxiranylmethyl)-

[英文别名 ]:

EINECS 278-745-8
Anaxirone
Anaxirona [Spanish]
Anaxironum [Latin]
Triglycidylurazole
1,2,4-Triglycidyl urazol

阿那昔酮物理化学性质

[ 密度 ]:
1.596g/cm3

[ 沸点 ]:
405.8ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₁₅N₃O₅

[ 分子量 ]:
269.25400

[ 闪点 ]:
199.2ºC

[ 精确质量 ]:
269.10100

[ PSA ]:
86.52000

[ 折射率 ]:
1.639

阿那昔酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ5437000

CHEMICAL NAME :: 1,2,4-Triazolidine-3,5-dione, 1,2,4-tris(oxiranylmethyl)-

CAS REGISTRY NUMBER :: 77658-97-0

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H15-N3-O5

MOLECULAR WEIGHT :: 269.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,209,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 20,1187,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 27,67,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,209,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

REFERENCE :: CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 27,361,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 75 mg/kg/3D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - thrombocytopenia Related to Chronic Data - death

REFERENCE :: CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 27,361,1991

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