norbuprenorphine
norbuprenorphine名称
[ CAS 号 ]:
78715-23-8
[ 英文名 ]:
norbuprenorphine
[英文别名 ]:
- 6-Methylamino-4,4-diphenyl-3-heptanol-acetat
- Noracetylmethadol
- paracymethadol
- Noracetylmethadone
- Noracymethadole
norbuprenorphine物理化学性质
[ 密度 ]:
1.27g/cm3
[ 沸点 ]:
562.7ºC at 760 mmHg
[ 熔点 ]:
221-224ºC
[ 分子式 ]:
C25H35NO4
[ 分子量 ]:
413.55000
[ 闪点 ]:
294.1ºC
[ 精确质量 ]:
413.25700
[ PSA ]:
70.95000
[ LogP ]:
3.62020
[ 折射率 ]:
1.627
norbuprenorphine安全信息
[ 符号 ]:
GHS02, GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H301 + H311 + H331-H370
[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311
[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution
norbuprenorphine合成路线
norbuprenorphine上下游产品
norbuprenorphine上游产品
norbuprenorphine下游产品
norbuprenorphine文献
J. Pharmacol. Exp. Ther. 343(1) , 53-61, (2012)
Norbuprenorphine is a major metabolite of buprenorphine and potent agonist of μ, δ, and κ opioid receptors. Compared with buprenorphine, norbuprenorphine causes minimal antinociception but greater res...
Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.Bioconjug. Chem. 22(4) , 752-8, (2011)
Norbuprenorphine-3-β-d-glucuronide (nBPN-3-β-d-G, 1) is a major phase II metabolite of buprenorphine, a pharmaceutical used for the treatment of opioid addiction. The pharmacological activity of compo...
Preliminary buprenorphine sublingual tablet pharmacokinetic data in plasma, oral fluid, and sweat during treatment of opioid-dependent pregnant women.Ther. Drug Monit. 33(5) , 619-26, (2011)
Buprenorphine is currently under investigation as a pharmacotherapy to treat pregnant women for opioid dependence. This research evaluates buprenorphine (BUP), norbuprenophine (NBUP), buprenorphine-gl...
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