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DL-泛酰内酯

DL-泛酰内酯用途

DL-泛内酯可被尖孢镰刀菌的乳糖水解酶水解为泛油酸。DL-泛内酯也可用于制备3,5-二硝基苯甲酰基-DL-泛内酯[1][2]。

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DL-泛酰内酯名称

[ CAS 号 ]:
79-50-5

[ 中文名 ]:
DL-泛酰内酯

[ 英文名 ]:
DL-Pantolactone

[中文别名 ]:

[英文别名 ]:

(R)-(−)-Pantolactone
pantoyl lactone
2-oxo-4,4-dimethyl-3-hydroxy-tetrahydrofuran
MFCD00064333
(3R)-3-Hydroxy-4,4-dimethyldihydro-2(3H)-furanone
(D)-Pantolactone
rac-pantolactone
dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone
PANTOLACTONE
DL-PANTOYL LACTONE

DL-泛酰内酯生物活性

[ 描述 ]:

DL-泛内酯可被尖孢镰刀菌的乳糖水解酶水解为泛油酸。DL-泛内酯也可用于制备3,5-二硝基苯甲酰基-DL-泛内酯[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Goodhue CT, et, al. The bacterial degradation of pantothenic acid. 3. Enzymatic formation of aldopantoic acid. Biochemistry. 1966 Feb;5(2):403-8.

[2]. Shimizu S, et, al. Optical resolution of pantolactone by a novel fungal enzyme, lactonohydrolase. Ann N Y Acad Sci. 1996 Oct 12;799:650-8.

DL-泛酰内酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
224.6±0.0 °C at 760 mmHg

[ 熔点 ]:
74-78 °C(lit.)

[ 分子式 ]:
C₆H₁₀O₃

[ 分子量 ]:
130.142

[ 闪点 ]:
99.0±13.2 °C

[ 精确质量 ]:
130.062988

[ PSA ]:
49.83000

[ LogP ]:
-0.80

[ 外观性状 ]:
白色针状

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.469

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
水溶性：可溶；可溶于：氯仿,乙醇,苯,乙醚

DL-泛酰内酯MSDS

DL-泛酰内酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R22;R24/25

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

DL-泛酰内酯合成路线

DL-泛酰内酯上下游产品

DL-泛酰内酯上游产品

DL-泛酰内酯下游产品

DL-泛酰内酯制备

由异丁醛制得2,2-二甲基-3-羟基丙醛后，与氰化钠加成，再经水解酸化、内酯化而得。将2,2-二甲基-3-羟基丙醛溶解于水，投入反应锅，再投入氰化钠水溶液及氯化钙水溶液。搅匀后加入50%的硫酸溶液。反应产生剧毒的氰化氢尾气，用硫酸亚铁溶液吸收。于60-65℃反应6h后，升温至80-85℃反应3h，减压浓缩，加95%乙醇使无机盐沉淀。过滤，滤液减压回收乙醇后进行分馏，收集130-145℃（1.33-2.44kPa）馏分，得DL-泛酰内酯。

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DL-泛酰内酯文献

Potentially prebiotic syntheses of condensed phosphates.

Orig. Life Evol. Biosph. 26(1) , 15-25, (1996)

In view of the importance of a prebiotic source of high energy phosphates, we have investigated a number of potentially prebiotic processes to produce condensed phosphates from orthophosphate and cycl...

A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A.

Nature 373(6516) , 683-5, (1995)

The involvement of coenzyme A in many enzyme reactions suggests that it acted in this capacity very early in the development of life on Earth. Particularly relevant in this regard is its role in the a...

Optical rotation of noncovalent aggregates.

J. Am. Chem. Soc. 125(51) , 15696-7, (2003)

Dilute solutions of (R)-(-)-pantolactone in CCl4 were studied by polarimetry in conjunction with theoretical calculations of [alpha]D. Our data demonstrate that the self-association of a chiral solute...

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