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4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺盐酸盐

用途

舍曲林中间体

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名称

[ CAS 号 ]:
79617-89-3

[ 中文名 ]:
舍曲林碱

[ 英文名 ]:
cis-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

[中文别名 ]:

[英文别名 ]:

(+/-)-sertraline hydrochloride

物理化学性质

[ 沸点 ]:
443.8ºC at 760 mmHg

[ 熔点 ]:
275-277ºC

[ 分子式 ]:
C₁₇H₁₈Cl₃N

[ 分子量 ]:
342.690

[ 闪点 ]:
222.2ºC

[ 精确质量 ]:
341.050476

[ PSA ]:
12.03000

[ LogP ]:
6.37250

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H412

[ 警示性声明 ]:
P273

[ 危险品运输编码 ]:
NONH for all modes of transport

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文献

Development and validation of LC-MSMS assay for the determination of the prodrug dabigatran etexilate and its active metabolites in human plasma.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 989 , 37-45, (2015)

Dabigatran etexilate (DABE) is a low-molecular-weight prodrug that is converted after oral administration to dabigatran (DAB)-a directly acting oral anticoagulant. In this study, an LC-MSMS assay was ...

Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats.

J. Ethnopharmacol. 155(3) , 1473-82, (2014)

Schisandra chinensis (SC), officially listed as a sedative and tonic in the Chinese Pharmacopoeia, has been used as a common component in various prescriptions in Traditional Chinese Medicine (TCM) an...

Cannabinoids prevent the effects of a footshock followed by situational reminders on emotional processing.

Neuropsychopharmacology 39(12) , 2709-22, (2014)

Posttraumatic stress disorder (PTSD) can develop following exposure to a traumatic event. Hence, what we do in the first few hours after trauma exposure may alter the trajectory of PTSD. We examined w...

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