甲基丙烯酸甲酯
甲基丙烯酸甲酯用途
主要用作有机玻璃的单体,也用于制其他塑料、涂料等
【用途二】
甲基丙烯酸甲酯是杀菌剂菌核净的中间体。
【用途三】
该品主要用作聚甲基丙烯酸甲酯(有机玻璃)的单体,也与其他乙烯基单体共聚得到不同性质的产品,也用于制造其他树脂、塑料、粘合剂、涂料、润滑剂、木材浸润剂、电机线圈浸透剂、离子交换树脂、纸张上光剂、纺织印染助剂、皮革处理剂和绝缘灌注材料等。
甲基丙烯酸甲酯名称
[ CAS 号 ]:
80-62-6
[ 中文名 ]:
甲基丙烯酸甲酯
[ 英文名 ]:
Methyl methacrylate
[中文别名 ]:
[英文别名 ]:
- EINECS 201-297-1
- 2-Propenoicacid, 2-methyl-, methyl ester
- Methyl methacrylate
- MFCD00008587
甲基丙烯酸甲酯物理化学性质
[ 密度 ]:
0.9±0.1 g/cm3
[ 沸点 ]:
100.3±0.0 °C at 760 mmHg
[ 熔点 ]:
-48ºC
[ 分子式 ]:
C5H8O2
[ 分子量 ]:
100.116
[ 闪点 ]:
10.0±0.0 °C
[ 精确质量 ]:
100.052429
[ PSA ]:
26.30000
[ LogP ]:
1.35
[ 外观性状 ]:
无色液体
[ 蒸汽密度 ]:
3.5 (vs air)
[ 蒸汽压 ]:
36.9±0.1 mmHg at 25°C
[ 折射率 ]:
1.400
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放,不宜久储,以防聚合
[ 水溶解性 ]:
15.9 g/L (20 ºC)
甲基丙烯酸甲酯MSDS
甲基丙烯酸甲酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OZ5075000
- CHEMICAL NAME :
- Methacrylic acid, methyl ester
- CAS REGISTRY NUMBER :
- 80-62-6
- BEILSTEIN REFERENCE NO. :
- 0605459
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 102
- MOLECULAR FORMULA :
- C5-H8-O2
- MOLECULAR WEIGHT :
- 100.13
- WISWESSER LINE NOTATION :
- 1UY1&VO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 125 ppm
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - excitement Behavioral - anorexia (human)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 60 mg/m3
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - excitement Vascular - BP lowering not characterized in autonomic section
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7872 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 78000 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1328 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7088 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3625 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18500 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 945 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5954 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4725 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 41200 mg/m3/3H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4252 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 120 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 7 mL/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Kidney, Ureter, Bladder - changes primarily in glomeruli Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 8700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 17500 mg/m3/4.5H
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 14 mL/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - hematuria
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 5954 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 19000 mg/m3/5H
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1890 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 5954 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 20 gm/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10500 mg/kg/21D-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - somnolence (general depressed activity) Biochemical - Metabolism (Intermediary) - lipids including transport
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17896 mg/kg/35W-I
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach Liver - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 116 ppm/8H/26W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in phosphorus Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5000 ppm/6H/14W-I
- TOXIC EFFECTS :
- Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 34500 mg/m3/16W-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 mg/m3/24H/60D-C
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 115 mg/m3/3H/17W-I
- TOXIC EFFECTS :
- Cardiac - EKG changes not diagnostic of specified effects Blood - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ppm/6H/2Y-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41 gm/m3/90M/15D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5000 ppm/6H/14W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Liver - hepatitis (hepatocellular necrosis), zonal Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 ppm/6H/2Y-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19665 mL/kg/15W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1825 mg/kg/2Y-C
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 47 gm/m3/90M/15D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 15 gm/m3/7H/5D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 97500 ug/kg/39W-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 15 gm/m3/7H/5D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 65 gm/m3/3H/3D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 400 ppm/6H/78W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1620 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 10 mg/m3
- SEX/DURATION :
- female 9 year(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Newborn - delayed effects
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 109 gm/m3/17M
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 109 gm/m3/54M
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 54 mg/m3/24H
- SEX/DURATION :
- female 8 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 4480 mg/m3/2H
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 405 mg/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 801 mg/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-314,1986 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 410 mg/m3 (100 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,187,1979 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,187,1979 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,445,1994 IARC Cancer Review:Animal LACK CARCINOGENICITY IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,445,1994 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,445,1994 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,141,1975 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 100 ppm (410 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,168,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (410 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (410 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (410 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (410 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 100 ppm (410 mg/m3) JAN 1993 OEL-BELGIUM:TWA 100 ppm (410 mg/m3) JAN 1993 OEL-DENMARK:TWA 75 ppm (307 mg/m3) JAN 1993 OEL-FINLAND:TWA 100 ppm (410 mg/m3);STEL 150 ppm (615 mg/m3) JAN 1993 OEL-FRANCE:TWA 100 ppm (410 mg/m3);STEL 200 ppm (820 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (210 mg/m3) JAN 1993 OEL-HUNGARY:TWA 50 mg/m3;STEL 150 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 100 ppm (410 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (410 mg/m3) JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 OEL-SWEDEN:TWA 50 ppm (200 mg/m3);STEL 150 ppm (600 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (210 mg/m3);STEL 100 ppm (420 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (410 mg/m3);STEL 125 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL METHACRYLATE-air:10H TWA 100 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 47700 No. of Facilities: 11522 (estimated) No. of Industries: 89 No. of Occupations: 73 No. of Employees: 89435 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 47700 No. of Facilities: 6757 (estimated) No. of Industries: 76 No. of Occupations: 80 No. of Employees: 170079 (estimated) No. of Female Employees: 59519 (estimated)
甲基丙烯酸甲酯安全信息
[ 符号 ]:
GHS02, GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H301 + H311 + H331-H370
[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
[ 危害码 (欧洲) ]:
F:Flammable
[ 风险声明 (欧洲) ]:
R11;R37/38;R43
[ 安全声明 (欧洲) ]:
S24-S37-S46
[ 危险品运输编码 ]:
UN 1247
[ WGK德国 ]:
1
[ RTECS号 ]:
OZ5075000
[ 包装等级 ]:
II
[ 危险类别 ]:
3.0
[ 海关编码 ]:
3824909990
甲基丙烯酸甲酯合成路线
甲基丙烯酸甲酯上下游产品
甲基丙烯酸甲酯上游产品
甲基丙烯酸甲酯下游产品
甲基丙烯酸甲酯制备
1.丙酮氰醇法
丙酮与氰化氢反应生成丙酮氰醇,丙酮氰醇与硫酸及甲醇反应,制得甲基丙烯酸甲酯,得到的粗酯经盐析、初馏、精馏得产品。
2.丙烯法
丙烯、一氧化碳与甲醇反应,合成中间体2-甲氧基-2-甲基丙酸甲酯,将它分解生成甲基丙烯酸甲酯和甲醇。
3.异丁烯法
将异丁烯用氧化剂在K2CO3或MnO2催化剂存在下氧化成甲基丙烯酸或用空气在钼催化剂存在下分两段氧化,即先氧化成甲基丙烯醛,进一步氧化成甲基丙烯酸,它再与甲醇酯化制得甲基丙烯酸甲酯。
4.丙炔羰基化法 壳牌公司近年开发了一种丙炔羰基化合成MMA的新工艺,并已实现了工业化。据称该法比目前正在生产的或者正在开发中的任工艺都简易,且成本低。
5.乙烯法 该法是将乙烯羰基化或加氢甲酰化生成C3的羰基化合物,然后再与甲醛或与之相当的化合物缩合成甲基丙烯酸甲酯。该工艺的主要优点在于产生的氢氰酸副产物可作为制取ACH的原料循环,并且不产生硫酸铵产物。
6.制法:
于装有搅拌器、回流冷凝器、温度基、滴液漏斗的反应瓶中,加入磷酸三甲苯酚酯75g,五氧化二磷9g,铜粉0.2g。搅拌下油浴加热至65℃,慢慢滴加2-羟基异丁酸甲酯(2)25g(0.2mol),控制反应温度不超过65℃。加完后,升温至80~100℃,并保持此温度反应3h,改为蒸馏装置,蒸出170℃以下的馏分。馏出液用10%的碳酸钠溶液洗涤,无水磷酸钠干燥,加入少量铜粉①重新蒸馏,收集97~100℃的馏分,得甲基丙烯酸甲酯②(1)16~18g。收率76%~88%。注:1、加入铜粉的目的是放置甲基丙烯酸甲酯的聚合,也可加入少量的硫黄或二苯胺。2、也可由丙酮、氰化钠和甲醇为原料来合成甲基丙烯酸甲酯。
甲基丙烯酸甲酯海关
[ 海关编码 ]: 3824909990
甲基丙烯酸甲酯文献
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【甲基丙烯酸甲酯】化源网提供甲基丙烯酸甲酯CAS号80-62-6,甲基丙烯酸甲酯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询甲基丙烯酸甲酯上化源网,专业又轻松。>>电脑版:甲基丙烯酸甲酯
标题:甲基丙烯酸甲酯_MSDS_用途_密度_CAS号【80-62-6】_化源网 地址:https://m.chemsrc.com/mip/cas/80-62-6_32386.html