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N-亚硝基降烟碱(NNN)

N-亚硝基降烟碱(NNN)用途

3-(1-亚硝异吡咯烷-2-基)吡啶是一种主要的烟草特有亚硝胺[1]。

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N-亚硝基降烟碱(NNN)名称

[ CAS 号 ]:
80508-23-2

[ 中文名 ]:
去甲基烟碱亚硝胺

[ 英文名 ]:
rac N'-Nitrosonornicotine

[英文别名 ]:

[3H]-(+/-)-N'-Nitrosonornicotine
nitroso-propyl-carbamic acid ethyl ester
N-Propyl-N-nitrosourethane
N-nitroso-N-n-propylurethane
3-(1-nitroso-pyrrolidin-2-yl)-pyridine
N-Propyl-N-nitrosourethan
N-Nitroso-N-propyl-urethan
CARBAMIC ACID,N-NITROSO-N-PROPYL-,ETHYL ESTER
1'-nitroso-6'-nor-nicotine
Nitroso-propyl-carbamidsaeure-aethylester

N-亚硝基降烟碱(NNN)生物活性

[ 描述 ]:

3-(1-亚硝异吡咯烷-2-基)吡啶是一种主要的烟草特有亚硝胺[1]。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Gao Y, Miksys S, Palmour RM, Tyndale RF. The Influence of Tobacco Smoke/Nicotine on CYP2A Expression in Human and African Green Monkey Lungs. Mol Pharmacol. 2020;98(6):658-668.

N-亚硝基降烟碱(NNN)物理化学性质

[ 沸点 ]:
154ºC at 0.2 MM HG

[ 熔点 ]:
43-45ºC

[ 分子式 ]:
C₉H₁₁N₃O

[ 分子量 ]:
177.20300

[ 闪点 ]:
9℃

[ 精确质量 ]:
177.09000

[ PSA ]:
45.56000

[ LogP ]:
1.83780

[ 储存条件 ]:
-20°C Freezer

N-亚硝基降烟碱(NNN)安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H351

[ 警示性声明 ]:
P281-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
25-40-39/23/24/25-23/24/25-11

[ 安全声明 (欧洲) ]:
36/37-45-16

[ 危险品运输编码 ]:
UN2811 6.1/PG 3

N-亚硝基降烟碱(NNN)合成路线

详细合成路线

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N-亚硝基降烟碱(NNN)上游产品

N-亚硝基降烟碱(NNN)下游产品

N-亚硝基降烟碱(NNN)文献

Genome-wide analysis of DNA methylation dynamics during early human development.

PLoS Genet. 10(12) , e1004868, (2014)

DNA methylation is globally reprogrammed during mammalian preimplantation development, which is critical for normal development. Recent reduced representation bisulfite sequencing (RRBS) studies sugge...

Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites.

Int. J. Cancer 134(10) , 2278-83, (2014)

The tobacco-specific nitrosamines N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are potent carcinogens for the rat esophagus and lung, respectively. Consistent w...

Evidence supporting product standards for carcinogens in smokeless tobacco products.

Cancer Prev. Res. (Phila.) 8(1) , 20-6, (2015)

Smokeless tobacco products sold in the United States vary significantly in yields of nicotine and tobacco-specific nitrosamines (TSNA). With the passage of the Family Smoking Prevention and Tobacco Co...

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