Salvinorin A

Salvinorin A用途

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway. Salvinorin A ameliorates cerebral vasospasm through activation of endothelial nitric oxide synthase in a rat model of subarachnoid hemorrhage.

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Salvinorin A名称

[ CAS 号 ]:
83729-01-5

[ 中文名 ]:
丹酚 A

[ 英文名 ]:
Salvinorin A(Divinorin A)

[英文别名 ]:

Divinorin A
salvonorin A
Salvinorin
Salvinorin A
MFCD05664742
Diviner's Sage
Mexican mint
herbal ecstasy

Salvinorin A物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
563.8±50.0 °C at 760 mmHg

[ 熔点 ]:
238-240ºC

[ 分子式 ]:
C₂₃H₂₈O₈

[ 分子量 ]:
432.464

[ 闪点 ]:
294.8±30.1 °C

[ 精确质量 ]:
432.178406

[ PSA ]:
109.11000

[ LogP ]:
1.82

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
-20°C，密闭，干燥

Salvinorin AMSDS

详细MSDS(安全技术说明书)

Salvinorin A安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,Xn

[ 风险声明 (欧洲) ]:
11-20/21/22-36

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN 1648 3 / PGII

[ RTECS号 ]:
QL6127142

Salvinorin A合成路线

详细合成路线

Salvinorin A上下游产品

Salvinorin A上游产品

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Salvinorin A文献

Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.

J. Pharmacol. Exp. Ther. 350(1) , 69-78, (2014)

The opioid and cannabinoid systems play a crucial role in multiple physiological processes in the central nervous system and in the periphery. Selective opioid as well as cannabinoid (CB) receptor ago...

Regulating a novel drug: an evaluation of changes in use of Salvia divinorum in the first year of Florida's ban.

Int. J. Drug Policy 23(6) , 512-21, (2012)

A plant with dissociative and psychoactive properties began to attract the attention of the media and United States policymakers following a well-publicized suicide in 2006 and reports that the plant ...

Development of an enzyme immunoassay using a monoclonal antibody against the psychoactive diterpenoid salvinorin A.

J. Nat. Prod. 76(9) , 1654-60, (2013)

Salvinorin A (1), the main active constituent in Salvia divinorum, is a highly selective kappa-opioid receptor agonist with hallucinogenic effects, which is regulated in several countries. In the pres...

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