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邻苯二甲酰亚胺

邻苯二甲酰亚胺用途

该品为染料、农药、医药、橡胶助剂等许多精细化学品的中间体，例如用于生产苯酞、邻苯二甲腈、靛蓝、杀菌剂灭菌丹、杀虫剂亚胺硫磷等等。

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邻苯二甲酰亚胺名称

[ CAS 号 ]:
85-41-6

[ 中文名 ]:
邻苯二甲酰亚胺

[ 英文名 ]:
O-Phthalimide

[中文别名 ]:

[英文别名 ]:

Phthalimide
PHTHALYLIMIDE
1H-Isoindole-1,3(2H)-dione
O-Phthalimide
EINECS 201-603-3
Benzoimide
Phthalimid
Ftalimmide
Phenylimide
O-PHTHALIC IMIDE

邻苯二甲酰亚胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
359.0±25.0 °C at 760 mmHg

[ 熔点 ]:
232-235 °C(lit.)

[ 分子式 ]:
C₈H₅NO₂

[ 分子量 ]:
147.131

[ 闪点 ]:
170.9±23.2 °C

[ 精确质量 ]:
147.032028

[ PSA ]:
46.17000

[ LogP ]:
0.80

[ 外观性状 ]:
白色片状

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.679

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
<0.1 g/100 mL at 19.5 ºC

邻苯二甲酰亚胺MSDS

详细MSDS(安全技术说明书)

邻苯二甲酰亚胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI3920000

CHEMICAL NAME :: Phthalimide

CAS REGISTRY NUMBER :: 85-41-6

BEILSTEIN REFERENCE NO. :: 0118522

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H5-N-O2

MOLECULAR WEIGHT :: 147.14

WISWESSER LINE NOTATION :: T56 BVMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,23,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 20,3,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1175 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,149,1964 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 6200 ug/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,172,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,172,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4388 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 22 No. of Employees: 1224 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4388 No. of Facilities: 334 (estimated) No. of Industries: 6 No. of Occupations: 18 No. of Employees: 8142 (estimated) No. of Female Employees: 1591 (estimated)

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邻苯二甲酰亚胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
TI3920000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2925190090

邻苯二甲酰亚胺制备

以苯酐为原料制取邻苯二甲酰亚胺的方法较多，工业生产实际应用的是碳铵法和尿素法。
1.碳铵法将苯酐和碳酸氢铵按摩尔比1：1.2混合，经粉碎机粉碎后投入反应釜，加热约4h升至200℃，再以稍快速度升温至280-300℃。将熔融物出料至结晶，冷却固化、粉碎即得成品，收率95%以上。每吨含量为95%的邻苯二甲酰亚胺需消耗苯酐1030kg、95%碳酸氢铵660kg。 2.尿素法

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邻苯二甲酰亚胺海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

邻苯二甲酰亚胺文献

Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives.

Bioorg. Med. Chem. Lett. 23(1) , 287-90, (2013)

Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yo...

Phthalimido-ferrocidiphenol cyclodextrin complexes: Characterization and anticancer activity.

Int. J. Pharm. 491 , 323-34, (2015)

Several ferrocenyl analogues of tamoxifen have already showed strong antiproliferative activity in experimental glioma models. Nevertheless, these compounds are very poorly soluble in water and an ada...

Azolyacetones as precursors to indoles and naphthofurans facilitated by microwave irradiation with simultaneous cooling.

Molecules 14(8) , 2976-84, (2009)

Phthalimide reacted with phenacyl bromide under microwave irradiation to yield phenacyl isoindolidene-1,3-dione (3b), while 3a reacted with phenylhydrazine to yield the phenylhydrazone 4 that was read...

更多文献

邻苯二甲酰亚胺

邻苯二甲酰亚胺用途

邻苯二甲酰亚胺名称

邻苯二甲酰亚胺物理化学性质

邻苯二甲酰亚胺MSDS

详细MSDS(安全技术说明书)

邻苯二甲酰亚胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

邻苯二甲酰亚胺安全信息

邻苯二甲酰亚胺制备

邻苯二甲酰亚胺海关

邻苯二甲酰亚胺文献

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