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Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase.

Proc. Natl. Acad. Sci. U. S. A. 110(14) , 5564-9, (2013)

Homology-directed repair (HDR) is a critical pathway for the repair of DNA double-strand breaks (DSBs) in mammalian cells. Efficient HDR is thought to be crucial for maintenance of genomic integrity d...

Helicobacter pylori DprA alleviates restriction barrier for incoming DNA.

Nucleic Acids Res. 41(5) , 3274-88, (2013)

Helicobacter pylori is a Gram-negative bacterium that colonizes human stomach and causes gastric inflammation. The species is naturally competent and displays remarkable diversity. The presence of a l...

Palindromic sequence impedes sequencing-by-ligation mechanism.

BMC Syst. Biol. 6 Suppl 2 , S10, (2012)

Current next-generation sequencing (NGS) platforms adopt two types of sequencing mechanisms: by synthesis or by ligation. The former is employed by 454 and Solexa systems, while the latter by SOLiD sy...

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