米托唑胺

米托唑胺名称

[ CAS 号 ]:
85622-95-3

[ 中文名 ]:
米托唑胺

[ 英文名 ]:
Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide,3-(2-chloroethyl)-3,4-dihydro-4-oxo-

[英文别名 ]:

米托唑胺物理化学性质

[ 密度 ]:
1.94g/cm3

[ 沸点 ]:
555.8ºC at 760 mmHg

[ 分子式 ]:
C7H7ClN6O2

[ 分子量 ]:
242.62200

[ 闪点 ]:
289.9ºC

[ 精确质量 ]:
242.03200

[ PSA ]:
108.17000

[ 折射率 ]:
1.834

米托唑胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ5927000
CHEMICAL NAME :
Imidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo-
CAS REGISTRY NUMBER :
85622-95-3
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C7-H7-Cl-N6-O2
MOLECULAR WEIGHT :
242.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
3108 ug/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
LD10 - Lethal Dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Blood - changes in cell count (unspecified) Blood - changes in bone marrow (not otherwise specified) Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
40 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
50 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,1767,1984
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