邻氨基苯甲酸肉桂酯
邻氨基苯甲酸肉桂酯用途
60多年前此化合物已用于食品和日化用品的加香，至１９７４年欧洲理事会确认此化合物对公众健康无害的人造香味料。
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邻氨基苯甲酸肉桂酯名称
[ CAS 号 ]:
87-29-6
[ 中文名 ]:
邻氨基苯甲酸肉桂酯
[ 英文名 ]:
2-Propen-1-ol,3-phenyl-, 1-(2-aminobenzoate)
[英文别名 ]:
- 3-PHENYL-2-PROPENYL ANTHRANILATE
- cinnamylo-aminobenzoate
- CINNAMYL ANTHRANILATE
- 2-aminobenzoic acid 3-phenyl-2-propenyl ester
- cinnamyl2-aminobenzoate
- MFCD00053631
- anthranilic acid trans-cinnamyl ester
- Anthranilsaeure-trans-cinnamylester
- cinnamylalcohol,anthranilate
- EINECS 201-738-8
邻氨基苯甲酸肉桂酯物理化学性质
[ 沸点 ]:
322ºC
[ 熔点 ]:
64-66ºC
[ 分子式 ]:
C16H15NO2
[ 分子量 ]:
253.29600
[ 闪点 ]:
322ºC
[ 精确质量 ]:
253.11000
[ PSA ]:
52.32000
[ LogP ]:
3.72020
[ 折射率 ]:
1.642
[ 储存条件 ]:
库房通风低温干燥
邻氨基苯甲酸肉桂酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CB2725000
- CHEMICAL NAME :
- Anthranilic acid, cinnamyl ester
- CAS REGISTRY NUMBER :
- 87-29-6
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C16-H15-N-O2
- MOLECULAR WEIGHT :
- 253.32
- WISWESSER LINE NOTATION :
- ZR BVO2U1R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 125 gm/kg/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg/3D-I
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39949 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg/3D-I
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 546 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1310 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 gm/kg/8W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2621 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1092 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 80 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8,515,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,133,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,133,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
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邻氨基苯甲酸肉桂酯安全信息
[ 安全声明 (欧洲) ]:
S22-S24/25
[ RTECS号 ]:
CB2725000
[ 海关编码 ]:
2922439000
邻氨基苯甲酸肉桂酯合成路线
邻氨基苯甲酸肉桂酯制备
由邻氨基苯甲酸与桂醇脱水酯化。
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邻氨基苯甲酸肉桂酯海关
[ 海关编码 ]: 2922439000
[ 中文概述 ]:
2922439000. 邻氨基苯甲酸(氨茴酸)盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:23(两用物项和技术进口许可证,两用物项和技术出口许可证). 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
[ Summary ]:
2922439000 anthranilic acid salts。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%
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