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(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯

(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯用途

K114,一种刚果红染料类似物,与淀粉样纤维紧密结合,其 EC50 值为 20-30 nM。

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(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯名称

[ CAS 号 ]:
872201-12-2

[ 中文名 ]:
(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯

[ 英文名 ]:
K 114

[英文别名 ]:

k114
hms3263m09

(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯生物活性

[ 描述 ]:

K114,一种刚果红染料类似物,与淀粉样纤维紧密结合,其 EC50 值为 20-30 nM。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. LeVine H 3rd, et al. Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114). Biochemistry. 2005 Dec 6;44(48):15937-43.

(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯物理化学性质

[ 分子式 ]:
C₂₂H₁₇BrO₂

[ 分子量 ]:
393.27

[ 精确质量 ]:
392.04100

[ PSA ]:
40.46000

[ LogP ]:
6.20110

[ 储存条件 ]:
-20°C，密闭，干燥

(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H413

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危险品运输编码 ]:
NONH for all modes of transport

(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯文献

Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.

PLoS ONE 7 , e38658, (2012)

TAR DNA-binding protein 43 (TDP-43) is a major component within ubiquitin-positive inclusions of a number of neurodegenerative diseases that increasingly are considered as TDP-43 proteinopathies. Iden...

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