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2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)用途

用于防止天然胶、合成胶及其合成树脂由于氧、热、紫外线、金属化合物所引起的老化

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2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)名称

[ CAS 号 ]:
88-24-4

[ 中文名 ]:
2,2'-亚甲基双(4-乙基-6-叔丁基苯酚)

[ 英文名 ]:
2,2'-Methylenebis(6-tert-butyl-4-ethylphenol)

[中文别名 ]:

[英文别名 ]:

MFCD00026296
EINECS 201-814-0
2,2'-Methylenebis(6-tert-butyl-4-ethylphenol)
Phenol, 2,2'-methylenebis[6-tert-butyl-4-ethyl-
2,2'-methanediylbis(6-tert-butyl-4-ethylphenol)

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
452.1±40.0 °C at 760 mmHg

[ 熔点 ]:
119-122 °C(lit.)

[ 分子式 ]:
C₂₅H₃₆O₂

[ 分子量 ]:
368.552

[ 闪点 ]:
187.5±21.9 °C

[ 精确质量 ]:
368.271515

[ PSA ]:
40.46000

[ LogP ]:
8.09

[ 外观性状 ]:
白色至淡奶油色结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.544

[ 储存条件 ]:
室温，干燥

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)MSDS

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL9800000

CHEMICAL NAME :: Phenol, 2,2'-methylenebis(6-tert-butyl-4-ethyl-

CAS REGISTRY NUMBER :: 88-24-4

BEILSTEIN REFERENCE NO. :: 2016207

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C25-H36-O2

MOLECULAR WEIGHT :: 368.61

WISWESSER LINE NOTATION :: 1X1&1&R BQ F2 C1R BQ D2 CX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17,135,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17,135,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 gm/kg/12W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17,135,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16800 mg/kg/4W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 18,49,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32760 mg/kg/78W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 16,15,1996 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 110,29,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9392 No. of Facilities: 90 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 5106 (estimated) No. of Female Employees: 2789 (estimated)

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2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
SL9800000

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)合成路线

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)上下游产品

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)上游产品

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)下游产品

2,2'-亚甲基双(6-叔丁基-4-乙基苯酚)文献

Toxicity studies of a synthetic antioxidant, 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rats. 2. Uncoupling effect on oxidative phosphorylation of liver mitochondria.

J. Toxicol. Sci. 18(1) , 49-55, (1993)

Effects of 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) (MBEBP) on hepatic mitochondrial oxidative phosphorylation in vitro, and on hepatic peroxisomal enzymes activities and microsomal mixed-functi...

[Distribution of 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rat tissues].

Eisei Shikenjo Hokoku. (105) , 26-8, (1987)

[Distribution of 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rat fat].

Eisei Shikenjo Hokoku. (106) , 105-6, (1988)

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