5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(4-morpholinyl)-a-lyxo-hexopyranosyl]oxy]-,hydrochloride, (8S,10S)- (9CI)

名称

[ 英文名 ]:
5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(4-morpholinyl)-a-lyxo-hexopyranosyl]oxy]-,hydrochloride, (8S,10S)- (9CI)

[英文别名 ]:

Morpholinoadriamycin

物理化学性质

[ 沸点 ]:
842.4ºC at 760 mmHg

[ 分子式 ]:
C₃₁H₃₆ClNO₁₂

[ 分子量 ]:
650.07000

[ 闪点 ]:
463.2ºC

[ 精确质量 ]:
649.19300

[ PSA ]:
192.52000

[ LogP ]:
1.11470

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9426040

CHEMICAL NAME :: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-8-(hydroxyacetyl)-1-methoxy-10-(( 2,3,6-trideoxy- 3-(4-morpholinyl)-alpha-lyxo-hexopyranosyl)oxy)-6,8,1 1-trihydroxy-, hydrochloride, (8S-cis)-

CAS REGISTRY NUMBER :: 89196-04-3

LAST UPDATED :: 199303

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C31-H35-N-O12.Cl-H

MOLECULAR WEIGHT :: 650.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Musculoskeletal - other changes Nutritional and Gross Metabolic - dehydration

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-211144

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 90 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Musculoskeletal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-211144

点击显示