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明胶

明胶用途

明胶是半透明、无色、无味的食物成分,通常来自动物身体部位的胶原蛋白。明胶是用于固化液体培养基的胶凝剂[1]。
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明胶名称

[ CAS 号 ]:
9000-70-8

[ 中文名 ]:
明胶

[ 英文名 ]:
Gelatin

[英文别名 ]:

明胶生物活性

[ 描述 ]:

明胶是半透明、无色、无味的食物成分,通常来自动物身体部位的胶原蛋白。明胶是用于固化液体培养基的胶凝剂[1]。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[参考文献]

[1]. Alvin Bacero Bello, et al. Engineering and Functionalization of Gelatin Biomaterials: From Cell Culture to Medical Applications. Tissue Eng Part B Rev. 2020 Apr;26(2):164-180.

明胶物理化学性质

[ 分子式 ]:
AlH3KO8S2

[ 分子量 ]:
261.22900

[ 精确质量 ]:
260.87200

[ PSA ]:
177.28000

[ 外观性状 ]:
powder

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Hygroscopic. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
H2O: 67 mg/mL at 50 °C, slightly hazy, slightly yellow | SOLUBLE IN HOT WATER

明胶MSDS

明胶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LX8580000
CHEMICAL NAME :
Gelatins
CAS REGISTRY NUMBER :
9000-70-8
LAST UPDATED :
199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
700 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,981,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 34715 No. of Facilities: 9213 (estimated) No. of Industries: 81 No. of Occupations: 59 No. of Employees: 64210 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8717 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 665 (estimated) No. of Female Employees: 314 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 34715 No. of Facilities: 13735 (estimated) No. of Industries: 92 No. of Occupations: 89 No. of Employees: 169507 (estimated) No. of Female Employees: 72931 (estimated)
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明胶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
24/25-36/37/39-27-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LX8580000

[ 海关编码 ]:
3503001001

明胶制备

1.一般由新鲜牛奶经脱脂、加酸(乳酸、醋酸、盐酸或硫酸均可)凝固、干燥而制得。

新鲜牛奶→脱脂35~40℃沉淀↓酸(pH=46)→清洗→

甩水→干燥→成品

2.主要方法有石灰乳法和盐酸法两种制法。石灰乳法 将牛皮、猪皮等变质的下脚皮的内层油脂刮去,切块,放在3.0%~4.0%的石灰乳中浸泡30~40d,并经常搅拌,中间换石灰乳4~6次。浸泡后的生皮取出、洗净,在搅拌下用10%的盐酸中和3~4h,使pH值在6.0~6.5。然后按1;1加水,加热至60~70℃蒸煮,每隔一定时间抽取胶水。将稀胶水送入蒸发器浓缩,使相对密度为1.03~1.07。冷却、干燥,温度控制在28℃左右。粉碎得成品。

盐酸法 将碎骨在45~50℃下用苯提油后水洗,用3.5盐酸法 将碎骨在45~50℃下用苯提油后水洗,用3.5%~4.5%的盐酸浸泡软化得骨素粗品。水洗至pH值3.5左右,再用3.0%~3.5%的石灰乳浸泡30~50d,中间换石灰乳5~6次。取出后水洗,用0.2%盐酸中和至pH值3.5~4.0,放掉中和液另加清水,再用0.5%盐酸中和至pH值3.0。清水洗涤,浸泡4~5h,然后用稀氢氧化钠溶液洗涤,浸泡16~20h后用水冲洗,得到精制骨素。骨素在64~85℃下熬胶7道,得到的胶水经浓缩、干得明胶。

3.以动物皮、骨及结缔组织为原料,经提纯和初级水解后加工制得。

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明胶海关

[ 海关编码 ]: 3503001001

明胶文献

Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.

J. Biol. Chem. 290 , 16723-43, (2015)

Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splic...

Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke.

Mol. Brain 6 , 14, (2013)

Matrix metalloproteinases are important factors in the molecular mechanisms leading to neuronal injury in many neurological disorders. Matrix metalloproteinase (MMP)-9 is up-regulated after cerebral i...

Relating the variation of secondary structure of gelatin at fish oil-water interface to adsorption kinetics, dynamic interfacial tension and emulsion stability.

Food Chem. 143 , 484-91, (2014)

The objectives of this study were to quantify the relationship between secondary structure of gelatin and its adsorption at the fish-oil/water interface and to quantify the implication of the adsorpti...


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