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核糖核酸酶 A

核糖核酸酶 A用途

核糖核酸酶A将RNA 3′切割成嘧啶,并在每个嘧啶残基处主动切割RNA。核糖核酸酶A在没有金属离子或辅因子的情况下催化单链RNA的水解[1][2][3]。

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核糖核酸酶 A名称

[ CAS 号 ]:
9001-99-4

[ 中文名 ]:
核糖核酸酶 A

[ 英文名 ]:
Ribonuclease A

[英文别名 ]:

Ribonuclease A
MFCD00132181
Histidine, β-alanyl-
b-Alanylhistidine
β-Alanylhistidine
carnosine
EINECS 232-646-6
N-(3-Aminopropanoyl)histidine

核糖核酸酶 A生物活性

[ 描述 ]:

核糖核酸酶A将RNA 3′切割成嘧啶,并在每个嘧啶残基处主动切割RNA。核糖核酸酶A在没有金属离子或辅因子的情况下催化单链RNA的水解[1][2][3]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

核糖核酸酶 A物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
656.2±55.0 °C at 760 mmHg

[ 熔点 ]:
243 ºC (dec.)

[ 分子式 ]:
C₉H₁₄N₄O₃

[ 分子量 ]:
226.232

[ 闪点 ]:
350.7±31.5 °C

[ 精确质量 ]:
226.106583

[ LogP ]:
-2.17

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
-20°C

核糖核酸酶 A安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RF0760000

核糖核酸酶 A制备

以牛胰为原料稀酸抽提后用硫酸铵分级沉淀，在乙醇中重结晶制取。由红霉素产生的蓖的发酵液提取

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核糖核酸酶 A文献

2-Iodohexadecanal inhibits thyroid cell growth in part through the induction of let-7f microRNA.

Mol. Cell. Endocrinol. 414 , 224-32, (2015)

It is well known that pituitary TSH exerts the major task in the regulation of thyroid function. However, this gland is capable of certain degree of autonomy, independently of TSH control. Iodine play...

Electrodynamic pressure modulation of protein stability in cosolvents.

Biochemistry 52(46) , 8363-73, (2013)

Cosolvents affect structural stability of proteins in aqueous solutions. A clear understanding of the mechanism by which cosolvents impact protein stability is critical to understanding protein foldin...

Striking stabilization of Rana catesbeiana ribonuclease 3 by guanidine hydrochloride.

FEBS Lett. 587(6) , 737-42, (2013)

Unfolding by chemical denaturants and the linear extrapolation method are widely used to determine the free energy of proteins. Ribonuclease 3 from bullfrog shows an extraordinary behavior in guanidin...

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