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氟鼠酮

氟鼠酮用途

Flocoumafen(WL 108366)是第二代抗凝血灭鼠剂(ARs),属于维生素K拮抗剂(VKA)分子家族[1][2]。
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氟鼠酮名称

[ CAS 号 ]:
90035-08-8

[ 中文名 ]:
氟鼠灵

[ 英文名 ]:
Flocoumafen

[中文别名 ]:

[英文别名 ]:

氟鼠酮生物活性

[ 描述 ]:

Flocoumafen(WL 108366)是第二代抗凝血灭鼠剂(ARs),属于维生素K拮抗剂(VKA)分子家族[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> 其他 >> 其他

[参考文献]

[1]. Nadia Coronado-Posada, et al. In Silico Analysis to Identify Molecular Targets for Chemicals of Concern: The Case Study of Flocoumafen, an Anticoagulant Pesticide. Environ Toxicol Chem. 2021 Jul;40(7):2034-2043.

[2]. Sébastien Lefebvre, et al. Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences.

氟鼠酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
672.4±55.0 °C at 760 mmHg

[ 熔点 ]:
181-191 (cis-isomer). 163-166 (trans- isomer)ºC

[ 分子式 ]:
C33H25F3O4

[ 分子量 ]:
542.544

[ 闪点 ]:
360.5±31.5 °C

[ 精确质量 ]:
542.170471

[ PSA ]:
59.67000

[ LogP ]:
8.77

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.629

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

氟鼠酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ3100300
CHEMICAL NAME :
2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-((4-(trifluorome thyl)phenyl) methoxy)phenyl)-1-naphthalenyl)-
CAS REGISTRY NUMBER :
90035-08-8
LAST UPDATED :
199506
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C33-H25-F3-O4
MOLECULAR WEIGHT :
542.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C285,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
75 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - gerbil
DOSE/DURATION :
180 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,398,1991 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
JANREH Journal of Applied Animal Research. (Garuda Scientific Publications, 151, Janakpuri, Izatnagar, 243122, India) V.1- 1992- Volume(issue)/page/year: 2,81,1992
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氟鼠酮安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330-H372-H410

[ 警示性声明 ]:
P273-P314-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
26/27/28-48/23/24/25-50/53

[ 安全声明 (欧洲) ]:
28-36/37/39-45-60-61

[ 危险品运输编码 ]:
UN 3027

[ RTECS号 ]:
DJ3100300

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

氟鼠酮制备

3-[4-（4-三氟甲基苄氧基）苯基]-1，2，3，4-四氢-1-萘酚的制备 由4-三氟甲基溴苄与萘满酮在DMF中于室温反应，反应产物用NaBH4还原制得。
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氟鼠酮文献

Fast targeted analysis of 132 acidic and neutral drugs and poisons in whole blood using LC-MS/MS.

Forensic Sci. Int. 243 , 35-43, (2014)

The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction...

Acquired coagulopathy caused by intoxication with the superwarfarin-type anticoagulant rodenticide flocoumafen.

Eur. J. Haematol. 86(2) , 173-5, (2011)

A 28 year-old heretofore healthy woman was transferred to our hospital with a two-month history of recurring episodes of bleeding. Administration of vitamin K and prothrombin complex concentrates in t...

Metabolic and toxicological studies on the anticoagulant rodenticide, flocoumafen.

Arch. Toxicol. Suppl. 14 , 160-5, (1991)


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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

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联系人：徐经理

产品详情：氟鼠酮

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥3810.9/100mg ￥617.9/10mg ￥2162.9/50mg ￥需询单/100g

联系人：阿拉丁

产品详情：氟鼠酮

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