羟丙基纤维素

羟丙基纤维素用途

羟丙基纤维素具有一定的两亲性,是一种表面活性剂。羟丙基纤维素可作为药用辅料,如包衣剂、乳化剂、悬浮液、片剂、增稠剂、增粘剂等。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

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羟丙基纤维素名称

[ CAS 号 ]:
9004-64-2

[ 中文名 ]:
羟丙纤维素

[ 英文名 ]:
Hydroxypropyl Cellulose

[中文别名 ]:

[英文别名 ]:

Klucel
MFCD00132688

羟丙基纤维素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Werbowyj R S, et al. Liquid crystalline structure in aqueous hydroxypropyl cellulose solutions[J]. Molecular Crystals and Liquid Crystals, 1976, 34(4): 97-103.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

羟丙基纤维素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
891.2±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₆H₇₀O₁₉

[ 分子量 ]:
806.930

[ 闪点 ]:
492.8±34.3 °C

[ 精确质量 ]:
806.451111

[ LogP ]:
-1.24

[ 外观性状 ]:
powder | White to light cream

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.532

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

[ 水溶解性 ]:
polar oganic solvents: soluble

羟丙基纤维素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
S24/S25

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
NF9050000

羟丙基纤维素制备

（1）用碱和氯化丙烯处理纤维素；（2）用高浓度氢氧化钠浸渍处理木浆或木素浆，生成碱性纤维素溶液，将此溶液过滤及压榨，除去过剩的氢氧化钠后，进一步与环氧丙烷反应而得。

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羟丙基纤维素文献

Polymer-directed crystallization of atorvastatin.

J. Pharm. Sci. 101(8) , 2941-51, (2012)

Living organisms secrete minerals composed of peptides and proteins, resulting in "mesocrystals" of three-dimensional-assembled composite structures. Recently, this biomimetic polymer-directed crystal...

Stabilization of fenofibrate in low molecular weight hydroxypropylcellulose matrices produced by hot-melt extrusion.

Drug Dev. Ind. Pharm. 39(2) , 290-8, (2013)

The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecu...

Improved supersaturation and oral absorption of dutasteride by amorphous solid dispersions.

Chem. Pharm. Bull. 60(11) , 1468-73, (2012)

In this study, amorphous solid dispersions containing dutasteride and various excipients, manufactured by spray-drying processes, were characterized to determine the effects on their ability to form s...

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